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Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas.
Souza Freitas, Valéria; Dos Santos, Jean Nunes; de Andrade Santos, Pedro Paulo; Nonaka, Cassiano Francisco Weege; Pereira Pinto, Leão; de Souza, Lélia Batista.
Afiliação
  • Souza Freitas V; Department of Health Sciences, Oral Cancer Research Group, State University of Feira de Santana, Feira de Santana, Bahia, Brazil.
  • Dos Santos JN; Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
  • de Andrade Santos PP; Oral Pathology Post-Graduation Program, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande Do Norte, 59056-000, Brazil.
  • Nonaka CFW; Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil.
  • Pereira Pinto L; Oral Pathology Post-Graduation Program, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande Do Norte, 59056-000, Brazil.
  • de Souza LB; Oral Pathology Post-Graduation Program, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande Do Norte, 59056-000, Brazil. leliabsouza@gmail.com.
Eur Arch Otorhinolaryngol ; 275(12): 3075-3082, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30361787
PURPOSE: To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. METHODS: Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma. RESULTS: Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (p = 0.359), -7 (p = 0.081), and -26 (p = 0 553), as well as the tissue inhibitors-1 (p = 0.657), and -2 (p = 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (p = 0.041). CONCLUSIONS: The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma Adenoide Cístico / Adenoma Pleomorfo / Inibidor Tecidual de Metaloproteinase-1 / Inibidor Tecidual de Metaloproteinase-2 / Metaloproteinases da Matriz Limite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma Adenoide Cístico / Adenoma Pleomorfo / Inibidor Tecidual de Metaloproteinase-1 / Inibidor Tecidual de Metaloproteinase-2 / Metaloproteinases da Matriz Limite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha