Your browser doesn't support javascript.
loading
Cafeteria Diet Feeding in Young Rats Leads to Hepatic Steatosis and Increased Gluconeogenesis under Fatty Acids and Glucagon Influence.
Maeda Júnior, Antonio Sueiti; Constantin, Jorgete; Utsunomiya, Karina Sayuri; Gilglioni, Eduardo Hideo; Gasparin, Fabiana Rodrigues Silva; Carreño, Fernando Olinto; de Moraes, Solange Marta Franzói; Rocha, Márcio; Natali, Maria Raquel Marçal; Ghizoni, Cristiane Vizioli de Castro; Bracht, Adelar; Ishii-Iwamoto, Emy Luiza; Constantin, Rodrigo Polimeni.
Afiliação
  • Maeda Júnior AS; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. jrmaedaopcao@gmail.com.
  • Constantin J; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. jconstantin@uem.br.
  • Utsunomiya KS; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. ksutsunomiya2@uem.br.
  • Gilglioni EH; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. gilglioni@hotmail.com.
  • Gasparin FRS; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. fabygasparin@hotmail.com.
  • Carreño FO; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. fer.carreno@gmail.com.
  • de Moraes SMF; Department of Morphophysiological Sciences, State University of Maringá, Maringá 87020-900, Paraná, Brazil. smfmoraes@uem.br.
  • Rocha M; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. marciorocha@mail.com.
  • Natali MRM; Department of Morphophysiological Sciences, State University of Maringá, Maringá 87020-900, Paraná, Brazil. mrmnatali@uem.br.
  • Ghizoni CVC; Department of Biochemistry, Laboratory of Liver Metabolism, State University of Maringá, Maringá 87020-900, Paraná, Brazil. crisvizioli@gmail.com.
  • Bracht A; Department of Biochemistry, Laboratory of Liver Metabolism, State University of Maringá, Maringá 87020-900, Paraná, Brazil. adebracht@uol.com.br.
  • Ishii-Iwamoto EL; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. eliiwamoto@uem.br.
  • Constantin RP; Department of Biochemistry, Laboratory of Biological Oxidations and Laboratory of Experimental Steatosis, State University of Maringá, Maringá 87020-900, Paraná, Brazil. rpconstantin@uem.br.
Nutrients ; 10(11)2018 Oct 23.
Article em En | MEDLINE | ID: mdl-30360555
Gluconeogenesis overstimulation due to hepatic insulin resistance is the best-known mechanism behind elevated glycemia in obese subjects with hepatic steatosis. This suggests that glucose production in fatty livers may differ from that of healthy livers, also in response to other gluconeogenic determinant factors, such as the type of substrate and modulators. Thus, the aim of this study was to investigate the effects of these factors on hepatic gluconeogenesis in cafeteria diet-induced obese adult rats submitted to a cafeteria diet at a young age. The livers of the cafeteria group exhibited higher gluconeogenesis rates when glycerol was the substrate, but lower rates were found when lactate and pyruvate were the substrates. Stearate or glucagon caused higher stimulations in gluconeogenesis in cafeteria group livers, irrespective of the gluconeogenic substrates. An increased mitochondrial NADH/NAD⁺ ratio and a reduced rate of 14CO2 production from [14C] fatty acids suggested restriction of the citric acid cycle. The higher glycogen and lipid levels were possibly the cause for the reduced cellular and vascular spaces found in cafeteria group livers, likely contributing to oxygen consumption restriction. In conclusion, specific substrates and gluconeogenic modulators contribute to a higher stimulation of gluconeogenesis in livers from the cafeteria group.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucagon / Dieta / Ácidos Graxos / Fígado Gorduroso / Gluconeogênese Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucagon / Dieta / Ácidos Graxos / Fígado Gorduroso / Gluconeogênese Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça