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The Thalamostriatal Projections Contribute to the Initiation and Execution of a Sequence of Movements.
Díaz-Hernández, Edgar; Contreras-López, Rubén; Sánchez-Fuentes, Asai; Rodríguez-Sibrían, Luis; Ramírez-Jarquín, Josué O; Tecuapetla, Fatuel.
Afiliação
  • Díaz-Hernández E; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
  • Contreras-López R; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
  • Sánchez-Fuentes A; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
  • Rodríguez-Sibrían L; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
  • Ramírez-Jarquín JO; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico.
  • Tecuapetla F; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, 04510 Ciudad de México, CDMX, Mexico. Electronic address: fatuel@ifc.unam.mx.
Neuron ; 100(3): 739-752.e5, 2018 11 07.
Article em En | MEDLINE | ID: mdl-30344045
One of the main inputs driving striatal activity is the thalamostriatal projection. While the hypothesis postulating that the different thalamostriatal projections contribute differentially to shape the functions of the striatum is largely accepted, existing technical limitations have hampered efforts to prove it. Here, through the use of electrophysiological recordings of antidromically photo-identified thalamostriatal neurons and the optogenetic inhibition of thalamostriatal terminals, we identify that the thalamostriatal projections from the parafascicular and the ventroposterior regions of the thalamus contribute to the smooth initiation and the appropriate execution of a sequence of movements. Our results support a model in which both thalamostriatal projections have specific contributions to the initiation and execution of sequences, highlighting the specific contribution of the ventroposterior thalamostriatal connection for the repetition of actions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tálamo / Corpo Estriado / Intenção / Movimento / Rede Nervosa Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tálamo / Corpo Estriado / Intenção / Movimento / Rede Nervosa Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos