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Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017.
Grillová, Linda; Noda, Angel A; Lienhard, Reto; Blanco, Orestes; Rodríguez, Islay; Smajs, David.
Afiliação
  • Grillová L; Department of Biology, Masaryk University, Brno, Czech Republic.
  • Noda AA; Department of Mycology-Bacteriology, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.
  • Lienhard R; Department of Bacteriology and Serology, Analyses and Diagnostics Medical Microbiology, La Chaux-de-Fonds, Switzerland.
  • Blanco O; Department of Mycology-Bacteriology, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.
  • Rodríguez I; Department of Mycology-Bacteriology, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.
  • Smajs D; Department of Biology, Masaryk University, Brno, Czech Republic.
J Infect Dis ; 219(7): 1138-1145, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30325448
BACKGROUND: The increased prevalence of syphilis in Cuba prompted us to map the circulating Treponema pallidum subsp. pallidum allelic profiles in this geographic region. METHODS: Samples were collected from 2012 to 2017, from 83 male patients with ulcers or skin lesions, and were examined using multilocus sequence typing. Additionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible mutations leading to macrolide and tetracycline resistance. RESULTS: Among 94% of fully typed strains, we found 7 different allelic profiles, of which 4 had not been previously described. More than 87% of patients were infected with the T. pallidum SS14-like group and only 8.2% with T. pallidum Nichols-like group. As in other countries, the 1.3.1 allelic profile (ie, SS14-like) was the most common. In addition, 1 of the newly described allelic profiles represents T. pallidum strains that arose by recombination events between members of different T. pallidum subgroups. More than 90% of patients were infected with treponemes harboring the A2058G mutation. However, we found no potential tetracycline-resistant T. pallidum mutations. CONCLUSIONS: Our results suggest that, in Cuba, tetracycline antibiotics could be used to treat syphilis in penicillin-allergic patients instead of macrolides.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treponema pallidum / Sífilis Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Male País/Região como assunto: Caribe / Cuba Idioma: En Revista: J Infect Dis Ano de publicação: 2019 Tipo de documento: Article País de afiliação: República Tcheca País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treponema pallidum / Sífilis Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Male País/Região como assunto: Caribe / Cuba Idioma: En Revista: J Infect Dis Ano de publicação: 2019 Tipo de documento: Article País de afiliação: República Tcheca País de publicação: Estados Unidos