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Assessment of plasma lactate and core-peripheral temperature gradient in association with stages of naturally occurring myxomatous mitral valve disease in dogs.
Soares, Felipe B; Pereira-Neto, Gláucia B; Rabelo, Rodrigo C.
Afiliação
  • Soares FB; Veterinary Hospital of the Faculty of Agronomy and Veterinary Medicine, University of Brasilia, Brasília, Brazil.
  • Pereira-Neto GB; Northern Sector of Clubs, Darcy Ribeiro Universitary Campus, Brasília, Brazil.
  • Rabelo RC; Veterinary Hospital of the Faculty of Agronomy and Veterinary Medicine, University of Brasilia, Brasília, Brazil.
J Vet Emerg Crit Care (San Antonio) ; 28(6): 532-540, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30294857
OBJECTIVE: To evaluate plasma lactate concentrations and core-peripheral temperature gradients as perfusion parameters in dogs with heart failure caused by myxomatous mitral valve disease (MMVD) and to determine whether the above perfusion parameters are correlated with disease stages. DESIGN: Prospective observational study. SETTING: University teaching hospital. ANIMALS: After excluding 129 dogs because of exclusion criteria, 7 dogs with heart failure classified as stage B2 and 10 dogs classified as stage C according to the American Heart Association (AHA)/American College of Cardiology (ACC) were included in the study. Six dogs without MMVD were evaluated as the control group. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the evaluated parameters, the plasma lactate concentrations were increased in stage C (median 3.70 mmol/L [33.3 mg/dL], interquartile range (IQR) 0.72 mmol/L [6.5 mg/dL]) compared with those in the control (median 2.80 mmol/L [25.2 mg/dL], IQR 0.8 mmol/L [7.2 mg/dL]; P = 0.024) and stage B2 groups (median 2.70 mmol/L [24.3 mg/dL], IQR 1.8 mmol/L [16.2 mg/dL]; P = 0.045). Significant differences were not observed in the core-peripheral temperature gradients among the control, stage B2, and stage C dogs. CONCLUSIONS: Dogs with structural heart disease as a result of MMVD may have occult tissue hypoperfusion in stage C that is demonstrated by hyperlactatemia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Temperatura Corporal / Ácido Láctico / Doenças do Cão / Doenças das Valvas Cardíacas / Valva Mitral Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Vet Emerg Crit Care (San Antonio) Assunto da revista: MEDICINA DE EMERGENCIA / MEDICINA VETERINARIA / TERAPIA INTENSIVA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Temperatura Corporal / Ácido Láctico / Doenças do Cão / Doenças das Valvas Cardíacas / Valva Mitral Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Vet Emerg Crit Care (San Antonio) Assunto da revista: MEDICINA DE EMERGENCIA / MEDICINA VETERINARIA / TERAPIA INTENSIVA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos