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Glomerular hyperfiltration and ß-2 microglobulin as biomarkers of incipient renal dysfunction in cancer survivors.
Tibúrcio, Fernanda R; Rodrigues, Karla E de S; Belisário, André R; Simões-E-Silva, Ana Cristina.
Afiliação
  • Tibúrcio FR; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Pediatric Nephrology Unity, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Rodrigues KES; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Pediatric Nephrology Unity, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Belisário AR; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Pediatric Nephrology Unity, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Simões-E-Silva AC; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Pediatric Nephrology Unity, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Future Sci OA ; 4(8): FSO333, 2018 Sep.
Article em En | MEDLINE | ID: mdl-30271618
Herein, we aimed to evaluate the occurrence of impaired renal function after cancer treatment with potentially nephrotoxic chemotherapy in children. A cross-sectional study was performed in 41 cancer survivors after chemotherapy with potentially nephrotoxic drugs. 26 (63.4%) children were detected with glomerular hyperfiltration, and urinary levels of ß-2 microglobulin (B2MG) were higher than reference range in all patients. Levels of B2MG were positively correlated with plasma creatinine and negatively correlated with glomerular filtration rate. Plasma creatinine, systolic blood pressure and cholesterol were independently associated with B2MG values. The final multivariate model for glomerular hyperfiltration risk included plasma levels of urea and of magnesium. Urinary levels of B2MG and glomerular hyperfiltration may emerge as potential biomarkers of early renal dysfunction in childhood cancer survivors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Future Sci OA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Future Sci OA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido