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Can maternal treatment with metformin during gestation and lactation cause metabolic and cardiovascular disorders in rat offspring?
Novi, Daniella R B S; Vidigal, Camila B; Marques, Bruno V D; Forcato, Simone; Raquel, Hiviny A; Zaia, Dimas A M; Zaia, Cássia T B V; Martins-Pinge, Marli C; Gerardin, Daniela C C; Ceravolo, Graziela S.
Afiliação
  • Novi DRBS; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Vidigal CB; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Marques BVD; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Forcato S; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Raquel HA; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Zaia DAM; Department of Chemistry, State University of Londrina, Londrina, Brazil.
  • Zaia CTBV; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Martins-Pinge MC; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Gerardin DCC; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
  • Ceravolo GS; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
Arch Physiol Biochem ; 126(3): 276-281, 2020 Jul.
Article em En | MEDLINE | ID: mdl-30270666
Objective: The aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring.Materials and methods: Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL).Results: At 75 days of life, male and female MET offspring presented similar blood pressure when compared with their CTR. The heart rate of female METGL was higher than in the CTRGL. The insulin sensitivity, basal glycaemia, body weight, Lee index of obesity, plasmatic concentration of triglycerides, total cholesterol and fat acid of male and female MET were similar to CTR groups. Lower fat pad deposition was observed in female METG and METGL.Conclusion: MET exposure during gestational and lactation does not program cardiovascular and metabolic alterations in adult offspring life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Lactação / Doenças Cardiovasculares / Exposição Materna / Doenças Metabólicas / Metformina Limite: Animals / Pregnancy Idioma: En Revista: Arch Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Lactação / Doenças Cardiovasculares / Exposição Materna / Doenças Metabólicas / Metformina Limite: Animals / Pregnancy Idioma: En Revista: Arch Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido