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Ovarian response after random-start controlled ovarian stimulation to cryopreserve oocytes in cancer patients.
Campos, Ana Paula Cb; Geber, Guilherme P; Hurtado, Rodrigo; Sampaio, Marcos; Geber, Selmo.
Afiliação
  • Campos APC; UFMG - Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil.
  • Geber GP; ORIGEN - Center for Reproductive Medicine, Belo Horizonte/MG, Brazil.
  • Hurtado R; ORIGEN - Center for Reproductive Medicine, Belo Horizonte/MG, Brazil.
  • Sampaio M; ORIGEN - Center for Reproductive Medicine, Belo Horizonte/MG, Brazil.
  • Geber S; UFMG - Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil.
JBRA Assist Reprod ; 22(4): 352-354, 2018 Nov 01.
Article em En | MEDLINE | ID: mdl-30264947
OBJECTIVE: To evaluate COS and oocyte retrieval results in ART treatment cycles initiated at any stage of the menstrual cycle (random start) in cancer patients, who could not postpone the onset of cancer treatment. METHODS: Prospective observational study of 26 women with cancer, with an indication to start cancer treatment within the next 20 days and wishing to preserve their fertility. Ovarian stimulation started immediately with FSH followed by GnRH antagonist for pituitary suppression and GnRH agonist for oocyte maturation. Treatment started from day 1 to day 14 of the menstrual cycle was considered to be in the follicular phase, and that started from day 15 to day 28 was considered to be in the luteal phase. Oocyte retrieval was performed 34 h after GnRH agonist administration. After identification and maturity classification, metaphase II oocytes were cryopreserved using vitrification. RESULTS: A total of 13 women had breast cancer, 4 ovarian cancer, 3 Central Nervous System cancer, 3 endometrial cancer, 2 cervical cancer and one bowel cancer. Thirteen patients started treatment during follicular phase and 13 during luteal phase. We found similar results for the duration of treatment, total dose of follicle stimulating hormone, number of ampoules of gonadotropin releasing hormone antagonist, mean number of follicles identified at ultrasound on the day of trigger and retrieval, number of aspirated oocytes and Metaphase II oocytes. CONCLUSION: Random-start controlled ovarian stimulation for emergency fertility preservation for minimizing delay in oncologic treatment for cancer patients does not interfere with the number of metaphase II oocytes, and therefore can be routinely used for stimulation followed by cryopreservation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indução da Ovulação / Recuperação de Oócitos / Preservação da Fertilidade / Ciclo Menstrual Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Indução da Ovulação / Recuperação de Oócitos / Preservação da Fertilidade / Ciclo Menstrual Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil