Your browser doesn't support javascript.
loading
The hydroethanolic Litchi chinensis leaf extract alleviate hepatic injury induced by carbon tetrachloride (CCl4) through inhibition of hepatic inflammation.
Carolini Thiesen, Liliani; de Oliveira Nunes, Maria Luisa; Meyre-Silva, Christiane; Dávila Pastor, Veronica; de Andrade, Sérgio Faloni; Garcia Couto, Angélica; da Silva, Luisa Mota; Bellé Bresolin, Tania Mari; Santin, José Roberto.
Afiliação
  • Carolini Thiesen L; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil.
  • de Oliveira Nunes ML; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil.
  • Meyre-Silva C; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil.
  • Dávila Pastor V; Pharmacy Course, Universidade do Vale de Itajaí (UNIVALI), Itajaí, SC, Brazil.
  • de Andrade SF; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil; Pharmacy Course, Universidade do Vale de Itajaí (UNIVALI), Itajaí, SC, Brazil.
  • Garcia Couto A; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil; Pharmacy Course, Universidade do Vale de Itajaí (UNIVALI), Itajaí, SC, Brazil.
  • da Silva LM; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil; Pharmacy Course, Universidade do Vale de Itajaí (UNIVALI), Itajaí, SC, Brazil.
  • Bellé Bresolin TM; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil; Pharmacy Course, Universidade do Vale de Itajaí (UNIVALI), Itajaí, SC, Brazil.
  • Santin JR; Postgraduation Program in Pharmaceutical Sciences, Itajaí, SC, Brazil; Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Itajaí, SC, Brazil. Electronic address: jrs.santin@univali.br.
Biomed Pharmacother ; 107: 929-936, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30257405
Various medicinal plants are traditionally used in a hepatoprotective manner, like, for example, the Litchi chinensis leaf infusion that is employed in Chinese medicine as liver tonics to strengthen hepatic functioning. In this context, the present study was designed to evaluate the hepatoprotective and acute toxicological effects of hydroethanolic L. chinensis leaf extract in HepG2 cells and mice. Specifically, the cytotoxicity and hepatoprotective activities of L. chinensis leaf extract were evaluated in HepG2 cells and in vivo against carbon tetrachloride (CCl4)-induced acute liver injury. The administration of CCl4 in mice provokes cell swelling, loss of sinusoid capillary spaces and structural disarrangement of the hepatic lobe, apoptosis and leukocyte infiltration. Further, CCl4 evokes an increase in serum alanine aminotransferase (ALT), tumor necrosis factor (TNF) and interleukin-6 (IL-6) levels in hepatic tissue. However, Silymarin, the positive control, and the L. chinensis extract were able to restore the viability of cells treated with CCl4 at all concentrations evaluated, reduced the inflammatory parameters, TNF and IL-6, reestablished hepatic tissue morphology and did not induce acute toxicological alterations. The data obtained underscore that the extract from L. chinensis leaves features hepatoprotective activity, corroborating with ethnopharmacological use, and does not lead to acute toxicological effects.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Litchi / Doença Hepática Induzida por Substâncias e Drogas / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Litchi / Doença Hepática Induzida por Substâncias e Drogas / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: França