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Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay.
Netto, A O; Gelaleti, R B; Corvino, S B; Serrano, R G; Hernández, S C; Volpato, G T; Rudge, M V C; Braz, M G; Damasceno, D C.
Afiliação
  • Netto AO; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Gelaleti RB; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Corvino SB; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Serrano RG; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Hernández SC; Biochemical Department, Havana Medical Science University, ICBP Victoria de Girón, Havana, Cuba.
  • Volpato GT; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil; Laboratory of System Physiology and Reproductive Toxicology, Institute of Bio
  • Rudge MVC; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Braz MG; Department of Anesthesiology, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil.
  • Damasceno DC; Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil. Electronic address: debora.damasceno@unesp.br.
Mutat Res Genet Toxicol Environ Mutagen ; 835: 11-15, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30249476
BACKGROUND: Fetal impairment caused by a deleterious intrauterine environment may have long-term consequences, such as oxidative stress and genetic damage. Rats born as small-for-gestational-age (SPA) were submitted to exercise (swimming) before and during pregnancy. The animals exhibited glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight, showing the benefit of exercise for these rats. We hypothesised that regular exercise in SPA during gestation could prevent DNA damage in these animals and in their offspring, contributing to altered fetal programming of metabolism in the offspring. Severe diabetes was induced by streptozotocin treatment, to obtain SPA newborns. At adulthood, pregnant SPA rats were randomly distributed into two groups: exercised (SPAex - submitted to swimming program) or not-exercised (SPA - sedentary rats). Post-partum, blood was collected for analysis of DNA damage (comet assay) and oxidative stress. SPAex rats presented lower DNA damage levels, decreased lipid peroxidation, and a lower rate of newborns classified as large-for-pregnancy-age. DNA damage was also lower in SPAex newborns. We conclude that swimming applied to SPA pregnant rats contributes to decreased DNA damage and lipid peroxidation in the dams, and decreased DNA damage and macrosomia in their offspring.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Efeitos Tardios da Exposição Pré-Natal / Natação / Dano ao DNA / Ensaio Cometa / Feto / Mães Limite: Animals / Pregnancy Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Efeitos Tardios da Exposição Pré-Natal / Natação / Dano ao DNA / Ensaio Cometa / Feto / Mães Limite: Animals / Pregnancy Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda