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Echocardiographic Measurements of Right Ventricular Mechanics in Infants with Bronchopulmonary Dysplasia at 36 Weeks Postmenstrual Age.
Ehrmann, Daniel E; Mourani, Peter M; Abman, Steven H; Poindexter, Brenda B; Morrow, Lindsey A; Wagner, Brandie D; Di Maria, Michael V.
Afiliação
  • Ehrmann DE; Department of Pediatrics; The University of Colorado School of Medicine. Electronic address: daniel.ehrmann@childrenscolorado.org.
  • Mourani PM; The University of Colorado School of Medicine; The Pediatric Heart Lung Center; Division of Pediatric Critical Care.
  • Abman SH; The University of Colorado School of Medicine; Division of Pediatric Pulmonary Medicine, Children's Hospital Colorado, Aurora, CO.
  • Poindexter BB; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Morrow LA; Department of Biostatistics and Informatics, University of Colorado School of Public Health.
  • Wagner BD; Department of Biostatistics and Informatics, University of Colorado School of Public Health.
  • Di Maria MV; The University of Colorado School of Medicine; Division of Pediatric Cardiology; Heart Institute, Children's Hospital Colorado, Aurora, CO.
J Pediatr ; 203: 210-217.e1, 2018 12.
Article em En | MEDLINE | ID: mdl-30244987
OBJECTIVE: To test the hypothesis that specific echocardiographic measurements of right ventricular (RV) mechanics at 36 weeks postmenstrual age (PMA) are associated with the severity of bronchopulmonary dysplasia (BPD). STUDY DESIGN: A subset of 93 preterm infants (born between 27 and 29 weeks of gestation) was selected retrospectively from a prospectively enrolled cohort. BPD was defined using the National Institutes of Health workshop definition, with modifications for oxygen reduction testing and altitude. The cohort was divided into no-BPD and BPD groups using previously published methodology for analyses. Echocardiographic measurements of RV function (ie, tricuspid annular plane systolic excursion, fractional area of change, systolic-to-diastolic ratio, tissue Doppler myocardial performance index, and RV strain), RV remodeling/morphology (end-systolic left ventricular eccentricity index), and RV afterload (pulmonary artery acceleration time measure) were evaluated at 36 weeks PMA. Multivariable logistic regression determined associations between RV measurements and BPD severity. RESULTS: Compared with the no-BPD cohort, the BPD group had lower birth weight z-scores (P = .04) and trended toward a male predominance (P = .08). After adjusting for birth weight z-score, gestational age, and sex, there were no between-group differences in echocardiographic measurements except for the eccentricity index (scaled OR [0.1-unit increase], 1.49; 95% CI, 1.13-2.12; P = .01). CONCLUSIONS: Among conventional and emerging echocardiographic measurements of RV mechanics, eccentricity index was the sole variable independently associated with BPD severity in this study. The eccentricity index may be a useful echocardiographic measurement for characterizing RV mechanics in patients with BPD at 36 weeks PMA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Displasia Broncopulmonar / Recém-Nascido Prematuro / Ecocardiografia Doppler / Função Ventricular Direita / Disfunção Ventricular Direita Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Displasia Broncopulmonar / Recém-Nascido Prematuro / Ecocardiografia Doppler / Função Ventricular Direita / Disfunção Ventricular Direita Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos