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Protective effects of Brazilian propolis supplementation on capillary regression in the soleus muscle of hindlimb-unloaded rats.
Tanaka, Masayuki; Kanazashi, Miho; Maeshige, Noriaki; Kondo, Hiroyo; Ishihara, Akihiko; Fujino, Hidemi.
Afiliação
  • Tanaka M; Department of Physical Therapy, Faculty of Human Sciences, Osaka University of Human Sciences, 1-4-1 Shojaku, Settsu, Osaka, 566-8501, Japan.
  • Kanazashi M; Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, 1-1 Gakuen-cho, Mihara, Hiroshima, 723-0053, Japan.
  • Maeshige N; Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo, 654-0142, Japan.
  • Kondo H; Department of Food Science and Nutrition, Nagoya Women's University, Nagoya, 4-21 Shioji-cho, Mizuho-ku, Nagoya, Aichi, 467-8611, Japan.
  • Ishihara A; Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-nihonmatsu-cho, Sakyo-ku, Kyoto, Kyoto, 606-8501, Japan.
  • Fujino H; Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe, Hyogo, 654-0142, Japan. fujino@phoenix.kobe-u.ac.jp.
J Physiol Sci ; 69(2): 223-233, 2019 Mar.
Article em En | MEDLINE | ID: mdl-30232713
The protective effects of Brazilian propolis on capillary regression induced by chronically neuromuscular inactivity were investigated in rat soleus muscle. Four groups of male Wistar rat were used in this study; control (CON), control plus Brazilian propolis supplementation (CON + PP), 2-week hindlimb unloading (HU), and 2-week hindlimb unloading plus Brazilian propolis supplementation (HU + PP). The rats in the CON + PP and HU + PP groups received two oral doses of 500 mg/kg Brazilian propolis daily (total daily dose 1000 mg/kg) for 2 weeks. Unloading resulted in a decrease in capillary number, luminal diameter, and capillary volume, and an increase in the expression of anti-angiogenic factors, such as p53 and TSP-1, within the soleus muscle. Brazilian propolis supplementation, however, prevented these changes in capillary structure due to unloading through the stimulation of pro-angiogenic factors and suppression of anti-angiogenic factors. These results suggest that Brazilian propolis is a potential non-drug therapeutic agent against capillary regression induced by chronic unloading.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Capilares / Músculo Esquelético / Substâncias Protetoras / Membro Posterior Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Physiol Sci Assunto da revista: FISIOLOGIA / TRAUMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Capilares / Músculo Esquelético / Substâncias Protetoras / Membro Posterior Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Physiol Sci Assunto da revista: FISIOLOGIA / TRAUMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão