Your browser doesn't support javascript.
loading
Gelling functional property, anti-inflammatory and antinociceptive bioactivities of ß-D-glucan from the edible mushroom Pholiota nameko.
Abreu, Hellen; Simas, Fernanda Fogagnoli; Smiderle, Fhernanda Ribeiro; Sovrani, Vanessa; Dallazen, Jorge Luiz; Maria-Ferreira, Daniele; Werner, Maria Fernanda; Cordeiro, Lucimara M C; Iacomini, Marcello.
Afiliação
  • Abreu H; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil.
  • Simas FF; Departament of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil.
  • Smiderle FR; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil; Pelé Pequeno Príncipe Research Institute, Faculdades Pequeno Príncipe, CEP 80250-060, Curitiba, PR, Brazil.
  • Sovrani V; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil.
  • Dallazen JL; Departament of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
  • Maria-Ferreira D; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil; Departament of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
  • Werner MF; Departament of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
  • Cordeiro LMC; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil.
  • Iacomini M; Departament of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR CEP 81531-980, Brazil. Electronic address: iacomini@ufpr.br.
Int J Biol Macromol ; 122: 1128-1135, 2019 Feb 01.
Article em En | MEDLINE | ID: mdl-30218731
A ß-D-glucan was obtained from the edible mushroom Pholiota nameko by hot aqueous extraction and purification. NMR and methylation analyses of the purified fraction (GHW-PN, 1.46% yield) indicated the presence of a (1 → 3)-linked ß-D-glucan, highly substituted (~27%) at O-6 by single units of ß-D-Glcp or by (1 → 6)-ß-D-Glcp fragments. The ß-glucan (at 0.5, 1, and 2%) showed shear thinning behavior and when the concentration of the solution increased, there was an increase in apparent viscosity. The ß-D-glucan presented gel-like behavior and thermal stability under a simulated pasteurization process, suggesting its potential as a thickening and gelling agent in products submitted to temperature variations. The ß-D-glucan at 0.3, 1.0 and 3.0 mg kg-1 significantly inhibited the inflammatory pain in 24.8, 56.9 and 82.3%, respectively, in the formalin-induced nociception in mice. The results pointed out that the ß-D-glucan (GHW-PN) isolated from P. nameko presents potential application for the food industry or for medical purposes.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pholiota / Glucanos / Analgésicos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pholiota / Glucanos / Analgésicos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda