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Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese.
Borengasser, Sarah J; Baker, Peter R; Kerns, Mattie E; Miller, Leland V; Palacios, Alexandra P; Kemp, Jennifer F; Westcott, Jamie E; Morrison, Seth D; Hernandez, Teri L; Garces, Ana; Figueroa, Lester; Friedman, Jacob E; Hambidge, K Michael; Krebs, Nancy F.
Afiliação
  • Borengasser SJ; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. sarah.borengasser@ucdenver.edu.
  • Baker PR; Section of Clinical Genetics and Metabolism, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Peter.BakerII@ucdenver.edu.
  • Kerns ME; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. MATTIE.KERNS@UCDENVER.EDU.
  • Miller LV; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Leland.Miller@ucdenver.edu.
  • Palacios AP; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. ali.palacios@yahoo.com.
  • Kemp JF; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. JENNIFER.KEMP@UCDENVER.EDU.
  • Westcott JE; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Jamie.Westcott@ucdenver.edu.
  • Morrison SD; School of Medicine, University of Oklahoma, Tulsa, OK 74135, USA. seth-morrison@ouhsc.edu.
  • Hernandez TL; Division of Endocrinology, Metabolism, & Diabetes, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Teri.Hernandez@ucdenver.edu.
  • Garces A; School of School of Nursing, University of Colorado, Aurora, CO 80045, USA. Teri.Hernandez@ucdenver.edu.
  • Figueroa L; Maternal and Infant Health Department, Institute of Nutrition of Central American and Panama, Guatemala 1188, Guatemala. agarces@incap.int.
  • Friedman JE; Maternal and Infant Health Department, Institute of Nutrition of Central American and Panama, Guatemala 1188, Guatemala. lfigueroa@incap.int.
  • Hambidge KM; Section of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Jed.Friedman@ucdenver.edu.
  • Krebs NF; Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA. Michael.Hambidge@ucdenver.edu.
Nutrients ; 10(9)2018 Sep 11.
Article em En | MEDLINE | ID: mdl-30208589
Elevated branched chain amino acids (BCAAs: valine, leucine, and isoleucine) are well-established biomarkers of obesity-associated insulin resistance (IR). Mounting evidence suggests that low- and middle-income countries are suffering from a "double burden" of both undernutrition (growth stunting) and overnutrition (obesity) as these countries undergo a "nutrition transition". The purpose of this study was to examine if pre-pregnancy body mass index (BMI, kg/m²) and a daily lipid-based micronutrient supplement (LNS, Nutriset) would lead to cross-sectional differences in circulating levels of branched chain amino acids (BCAAs) in Guatemalan women experiencing short stature during early pregnancy. Using data from an ongoing randomized controlled trial, Women First, we studied women who were normal weight (NW, BMI range for this cohort = 20.1⁻24.1 kg/m²) or overweight/obese (OW/OB, BMI range for this cohort = 25.6⁻31.9 kg/m²), and divided into two groups: those who received daily LNS ≥ 3 months prior to conception through 12 weeks gestation (+LNS), or no LNS (-LNS) (n = 9⁻10/group). BCAAs levels were obtained from dried blood spot card samples (DBS) assessed at 12 weeks gestation. DBS cards provide a stable, efficient, and reliable means of collecting, transporting, and storing blood samples in low resource or field settings. Circulating maternal leptin, adiponectin, and insulin were determined by immunoassays from serum samples collected at 12 weeks gestation. We found maternal pre-pregnancy body mass index (ppBMI) was associated with higher circulating BCAAs (r² = 0.433, p = 0.002) and higher leptin/adiponectin ratio (r = 0.466, p = 0.044) in -LNS mothers at 12 weeks gestation. +LNS mothers demonstrated no correlations between BCAAs or leptin/adiponectin ratio across ppBMI suggesting LNS may be effective at improving metabolic status in OW/OB mothers during early pregnancy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cuidado Pré-Concepcional / Micronutrientes / Suplementos Nutricionais / Aminoácidos de Cadeia Ramificada / Obesidade Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America central / Guatemala Idioma: En Revista: Nutrients Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cuidado Pré-Concepcional / Micronutrientes / Suplementos Nutricionais / Aminoácidos de Cadeia Ramificada / Obesidade Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy País/Região como assunto: America central / Guatemala Idioma: En Revista: Nutrients Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça