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Nature as a source of drugs for ophthalmology.
Pinheiro, Gleyse Karina Lopes de Oliveira; Araújo Filho, Irami de; Araújo Neto, Irami de; Rêgo, Amália Cinthia Meneses; Azevedo, Eduardo Pereira de; Pinheiro, Francisco Irochima; Lima Filho, Acácio Alves de Souza.
Afiliação
  • Pinheiro GKLO; Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Araújo Filho I; Department of Surgery, Universidade Potiguar, Laureate International Universities, Natal, RN, Brazil.
  • Araújo Neto I; Universidade Potiguar, Laureate International Universities, Natal, RN, Brazil.
  • Rêgo ACM; Department of Biotechnology, Universidade Potiguar, Laureate International Universities, Natal, RN, Brazil.
  • Azevedo EP; Department of Biotechnology, Universidade Potiguar, Laureate International Universities, Natal, RN, Brazil.
  • Pinheiro FI; Department of Biotechnology, Universidade Potiguar, Laureate International Universities, Natal, RN, Brazil.
  • Lima Filho AAS; Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Arq Bras Oftalmol ; 81(5): 443-454, 2018.
Article em En | MEDLINE | ID: mdl-30208150
Nature has always provided an unlimited source of biologically-active compounds. Since the beginning of mankind, humans have sought resources in fauna and flora to treat eye diseases. However, it was only after the Industrial Revolution that extracts of plants and substances of animal origin could be used safely, as has been determined by controlled interventional studies. Two major challenges faced by ocular pharmacology are the following: developing drugs that are able to reduce blindness due to glaucoma; and controlling the pain associated with eye surgery. The search for a drug that effectively lowers intraocular pressure and controls the progression of glaucoma has led to the development of various ocular hypotensive agents, such as physostigmine from the Physostigma venenosum plant. The anesthetic properties of cocaine, extracted from Erythroxylon coca, finally enabled surgical procedures in the eye. Several new natural compounds have been investigated in an attempt to identify substances with the potential to provide additional benefits to eye tissue and vision. Emerging evidence of anti-inflammatory, wound-healing, antimicrobial, antioxidant, antitumor, and antiangiogenic properties attributed to plant extracts and animal tissues has encouraged more investment in research in this area. Despite technological advances in synthesizing drugs, the pharmaceutical industry still seeks new active compounds from natural sources as well as from revisiting already-established naturally derived compounds. Although a large number of naturally-occurring compounds is known, this review article focuses on the bioactive substances with scientifically-proven benefits for ocular tissues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Extratos Vegetais / Oftalmopatias Limite: Humans Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Extratos Vegetais / Oftalmopatias Limite: Humans Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil