Adipose tissue palmitoleic acid is inversely associated with nonfatal acute myocardial infarction in Costa Rican adults.

Luan, D; Wang, D; Campos, H; Baylin, A

Luan, D; Wang, D; Campos, H; Baylin, A.

Afiliação

Luan D; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Wang D; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Campos H; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Centro de Investigación e Innovación en Nutricion Traslacional y Salud, Universidad Hispanoamericana, San Jose, Costa Rica.
Baylin A; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: abaylin@umich.edu.

Nutr Metab Cardiovasc Dis ; 28(10): 973-979, 2018 10.

Article em En | MEDLINE | ID: mdl-30207271

RESUMO

BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction. We examined whether adipose tissue palmitoleic acid was associated with nonfatal acute myocardial infarction in a representative population of Costa Rican adults. METHODS AND RESULTS: Odds ratios of nonfatal acute myocardial infarction by quintiles of adipose tissue palmitoleic acid were calculated using conditional logistic regression in a case-control study of 1828 cases and 1828 controls matched by age, sex, and area of residence. We observed an inverse relationship between nonfatal acute myocardial infarction and adipose tissue palmitoleic acid (OR for highest quintile compared to lowest quintile of palmitoleic acid: 0.55; 95% CI: 0.41, 0.75; P for trend: <0.0001). We additionally observed a significant positive association between adipose tissue palmitoleic acid and high-density lipoprotein cholesterol. CONCLUSION: These data demonstrate an inverse association between adipose tissue palmitoleic acid and nonfatal acute myocardial infarction; however, further research is required in order to better understand the opposing associations between palmitoleic acid and high-density lipoprotein cholesterol and systolic blood pressure.

Assuntos

Tecido Adiposo/química; Ácidos Graxos Monoinsaturados/análise; Infarto do Miocárdio/epidemiologia; Infarto do Miocárdio/metabolismo; Idoso; Biomarcadores/análise; Estudos de Casos e Controles; Costa Rica/epidemiologia; Regulação para Baixo; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Infarto do Miocárdio/diagnóstico; Medição de Risco; Fatores de Risco

Palavras-chave

Adipose tissue palmitoleic acid; Casecontrol study; Costa Rican adults; HDL cholesterol; Metabolic syndrome; Nonfatal acute myocardial infarction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Monoinsaturados / Tecido Adiposo / Infarto do Miocárdio Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: America central / Costa rica Idioma: En Revista: Nutr Metab Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda

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