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Micronucleus frequency is correlated with antioxidant enzyme levels in workers occupationally exposed to pesticides.
Xotlanihua-Gervacio, Maria Del Carmen; Guerrero-Flores, Mirna Citlali; Herrera-Moreno, José Francisco; Medina-Díaz, Irma Martha; Bernal-Hernández, Yael Yvette; Barrón-Vivanco, Briscia Socorro; Sordo, Monserrat; Rojas-García, Aurora Elizabeth.
Afiliação
  • Xotlanihua-Gervacio MDC; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
  • Guerrero-Flores MC; Posgrado en Ciencias Biológico Agropecuarias|, Unidad Académica de Agricultura, Km. 9 Carretera Tepic, Compostela, Xalisco, Nayarit, Mexico.
  • Herrera-Moreno JF; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
  • Medina-Díaz IM; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
  • Bernal-Hernández YY; Posgrado en Ciencias Biológico Agropecuarias|, Unidad Académica de Agricultura, Km. 9 Carretera Tepic, Compostela, Xalisco, Nayarit, Mexico.
  • Barrón-Vivanco BS; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
  • Sordo M; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
  • Rojas-García AE; Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, 63155. Ciudad de la Cultura s/n. Col. Centro, C.P. 63000, Tepic, Nayarit, Mexico.
Environ Sci Pollut Res Int ; 25(31): 31558-31568, 2018 Nov.
Article em En | MEDLINE | ID: mdl-30206828
Oxidative stress can cause DNA damage leading to nuclear anomalies such as micronuclei (MN). Antioxidant enzymes involved in protection against intracellular oxidative stress include glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT). Pesticide exposure induces oxidative stress and alters antioxidant defense mechanisms, including detoxification and scavenger enzymes. The aim of this study was to evaluate MN frequency in workers occupationally exposed to pesticides and their relationship with antioxidant enzyme activities. A cross-sectional study was conducted in 201 individuals, some of whom were dedicated to the spraying of pesticides. The cytokinesis-block micronucleus (CBMN) assay was conducted, and the activities of GPx, GR, SOD, and CAT were determined. The geometric mean (GM) of MN was 5.4 (1-26 MN). The GM for the antioxidant enzymes was 198.68 U/mL for GPx, 38.96 U/g Hb for GR, 94.78 U/mL for SOD, and 69.77 U/g Hb for CAT. There was a lower MN frequency in males than that in females, and a higher nuclear index. In addition, age affected MN frequency. There was a negative correlation between MN frequency and GPx activity, but a positive one between MN frequency and GR activity. These findings suggest the involvement of GPx in MN frequency.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Testes para Micronúcleos / Exposição Ocupacional / Poluentes Ocupacionais do Ar Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Testes para Micronúcleos / Exposição Ocupacional / Poluentes Ocupacionais do Ar Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Environ Sci Pollut Res Int Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha