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Daily Consumption of Chocolate Rich in Flavonoids Decreases Cellular Genotoxicity and Improves Biochemical Parameters of Lipid and Glucose Metabolism.
Leyva-Soto, Aldo; Chavez-Santoscoy, Rocio Alejandra; Lara-Jacobo, Linda Ramona; Chavez-Santoscoy, Ana Vianey; Gonzalez-Cobian, Lina Natalia.
Afiliação
  • Leyva-Soto A; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California-Campus Tijuana, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, C.P. 22390 Tijuana, Mexico. aldo.leyva@uabc.edu.mx.
  • Chavez-Santoscoy RA; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California-Campus Tijuana, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, C.P. 22390 Tijuana, Mexico. ale.santoscoy@gmail.com.
  • Lara-Jacobo LR; Laboratoire Écotoxiquegénomique, Eau Terre Environment, Institut national de la Recherche Scientifique (INRS-ETE), Rue 490 Couronne, Quebec City, QC G1K 9A9, Canada. linda_ramona.lara-jacobo@ete.inrs.ca.
  • Chavez-Santoscoy AV; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. anayenaiv@gmail.com.
  • Gonzalez-Cobian LN; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California-Campus Tijuana, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, C.P. 22390 Tijuana, Mexico. ngonzalez8@uabc.edu.mx.
Molecules ; 23(9)2018 Sep 01.
Article em En | MEDLINE | ID: mdl-30200398
In recent years, the incidence of atherosclerotic cardiovascular disease, obesity, and diabetes has increased largely worldwide. In the present work, we evaluated the genoprotective effect of the consumption of flavonoids-rich chocolate on 84 young volunteers. Biochemical indicators related to the prevention and treatment of cardiovascular risk and metabolic syndrome were also determined. A randomized, placebo-controlled, double-blind study was performed in the Autonomous University of Baja California. The treatments comprised the daily consumption of either 2 g of dark chocolate containing 70% cocoa, or 2 g of milk chocolate, for 6 months. The total amount of phenolic compounds and flavonoids was determined in both types of chocolate. Anthropometrical and Biochemical parameters were recorded prior to and after the study. The evaluation of the genotoxicity in buccal epithelial cells was performed throughout the duration of the study. Flavonoids from cocoa in dark chocolate significantly prevented DNA damage, and improved the nucleus integrity of cells. This effect could be related to the antioxidant capacity of the dark chocolate that decreased cellular stress. Biochemical parameters (total cholesterol, triglycerides, and LDL-cholesterol level in blood) and anthropometrical parameters (waist circumference) were improved after six months of daily intake of 2 g of dark chocolate with a 70% of cocoa.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Metabolismo dos Lipídeos / Chocolate / Glucose / Mutagênicos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Metabolismo dos Lipídeos / Chocolate / Glucose / Mutagênicos Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Suíça