[The organization of metabolism : subcellular localization of glycolytic enzymes]. / Organización del metabolismo: localización subcelular de enzimas glicolíticas.
Arch Biol Med Exp
; 18(1): 9-31, 1985 Mar.
Article
em Es
| MEDLINE
| ID: mdl-3019245
The subject of cellular metabolic organization (with focus on carbohydrate metabolism) is reviewed. The existence of a "soluble" phase in the cell is considered unlikely. A note of caution regarding metabolic compartmentation as shown by isotope studies is presented. Emphasis is given to the description of experiments purporting to show the influence of protein crowding, interactions between glycolytic enzymes, and reversible association to structural proteins or to organelles. The transient nature of those associations is considered to be particularly relevant to the organization and regulation of glycolysis. The proposed role of isozymes as structural determinants of metabolic compartmentation is stressed. A few studies based on immunocytochemical observations of glycolytic enzymes are briefly described. A list of questions whose answers are badly needed is presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfotransferases
/
Compartimento Celular
/
Metabolismo dos Carboidratos
/
Glicólise
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Arch Biol Med Exp
Ano de publicação:
1985
Tipo de documento:
Article
País de publicação:
Chile