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Influence of skeletal muscle mass and fat mass on the metabolic and inflammatory profile in sarcopenic and non-sarcopenic overfat elderly.
Rossi, Fabrício E; Lira, Fábio S; Silva, Bruna S A; Freire, Ana Paula C F; Ramos, Ercy M C; Gobbo, Luis A.
Afiliação
  • Rossi FE; Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), Teresina, PI, Brazil.
  • Lira FS; Exercise and Immunometabolism Research Group, School of Technology and Science, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
  • Silva BSA; Laboratory of Skeletal Muscle Assessment (LABSIM), Post-graduation Program in Movement Sciences, School of Technology and Science, São Paulo State University (UNESP), Rua Roberto Simonsen, 305, CEP 19.060-900, Presidente Prudente, SP, Brazil.
  • Freire APCF; Department of Physiotherapy, School of Technology and Science, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil.
  • Ramos EMC; Department of Physiotherapy, School of Technology and Science, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil.
  • Gobbo LA; Laboratory of Skeletal Muscle Assessment (LABSIM), Post-graduation Program in Movement Sciences, School of Technology and Science, São Paulo State University (UNESP), Rua Roberto Simonsen, 305, CEP 19.060-900, Presidente Prudente, SP, Brazil. luisgobbo@fct.unesp.br.
Aging Clin Exp Res ; 31(5): 629-635, 2019 May.
Article em En | MEDLINE | ID: mdl-30178443
BACKGROUND: Sarcopenic elderly present low muscle mass and strength, however, it is not clear if the inflammatory and metabolic profile is more related to low lean mass or high fat mass in sarcopenic and non-sarcopenic overfat elderly. AIM: To verify the difference in inflammatory and metabolic responses in sarcopenic and non-sarcopenic overfat elderly and the relationship between these markers, body composition, and strength in this population. METHODS: Fifty-seven elderly were divided into two groups: sarcopenic (n = 30) and non-sarcopenic (n = 27). Body composition was evaluated with octopolar bioimpedance. Total cholesterol, high-density lipoprotein cholesterol, triacylglycerol, glucose, cortisol, leptin, adiponectin, Plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-6, IL-8, and IL-10 were assessed. The handgrip test was used to evaluate strength. RESULTS: When comparing the inflammatory profile, sarcopenic individuals showed greater adiponectin concentration (p = 0.019), adiponectin/fat mass ratio (p < 0.001), adiponectin/visceral fat (p < 0.001), and higher PAI-1 (p = 0.019) than non-sarcopenic overfat elderly. After adjusting the inflammatory profile by skeletal muscle mass the significant differences between groups were maintained (p < 0.05) but no significant differences between groups were observed when adjusting by fat mass, despite a tendency to a significant difference for adiponectin concentration (p = 0.06). In addition, after adjusting leptin by fat mass there was a statistically significant lower concentration in the sarcopenic compared to non-sarcopenic overfat elderly. CONCLUSION: Non-sarcopenic overfat elderly presented lower anti-inflammatory and anti-atherogenic responses than sarcopenic elderly. Furthermore, fat mass but not skeletal muscle mass seem to change these responses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Músculo Esquelético / Força Muscular / Sarcopenia / Obesidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Músculo Esquelético / Força Muscular / Sarcopenia / Obesidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha