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Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma.
Vera-Tizatl, Adriana Leticia; Vera-Tizatl, Claudia Elizabeth; Vera-Hernández, Arturo; Leija-Salas, Lorenzo; Rodríguez, Sergio; Miklavcic, Damijan; Kos, Bor.
Afiliação
  • Vera-Tizatl AL; 1 Department of Electrical Engineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
  • Vera-Tizatl CE; 2 Department of Infectomics and Molecular Pathogenesis, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
  • Vera-Hernández A; 1 Department of Electrical Engineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
  • Leija-Salas L; 1 Department of Electrical Engineering, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico.
  • Rodríguez S; 3 Institute of Breast Diseases, FUCAM, Mexico City, Mexico.
  • Miklavcic D; 4 Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.
  • Kos B; 4 Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.
Technol Cancer Res Treat ; 17: 1533033818794939, 2018 01 01.
Article em En | MEDLINE | ID: mdl-30157721
Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging. The electrode models exhibit 4, 5, and 6 needles arranged in 4 geometric configurations (delta, diamond, and star) and 3 different needle spacing resulting in a total of 12 needle-electrode arrays. Electric field distribution in the tumors and a surrounding safety margin of 1 cm around the tumor edge is computed using the finite element method. Efficiency of the electrode arrays was determined hierarchically based on (1) percentage of tumor volume reversibly electroporated, (2) percentage of tumor volume irreversibly electroporated, (3) percentage of treated safety margin volume, (4) minimal invasiveness, that is, minimal number of electrodes used, (5) minimal activated electrode pairs, and (6) minimal electric current. Results show that 3 electrode arrays (4 needle-delta, 5 needle-diamond, and 6 needle-star) with fixed-geometry configuration could be used in the treatment with electrochemotherapy of invasive breast ductal carcinomas ranging from 1 to 5 cm3 along with a surrounding safety margin of 1 cm.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Ductal / Eletroquimioterapia Limite: Aged / Female / Humans / Middle aged Idioma: En Revista: Technol Cancer Res Treat Assunto da revista: NEOPLASIAS / TERAPEUTICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma Ductal / Eletroquimioterapia Limite: Aged / Female / Humans / Middle aged Idioma: En Revista: Technol Cancer Res Treat Assunto da revista: NEOPLASIAS / TERAPEUTICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos