Your browser doesn't support javascript.
loading
Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring.
Miranda, Rosiane Aparecida; da Silva Franco, Claudinéia Conationi; Previate, Carina; Alves, Vander Silva; Francisco, Flávio Andrade; Moreira, Veridiana Mota; de Moraes, Ana Maria Praxedes; Gomes, Rodrigo Mello; Picinato, Maria Cecília; Natali, Maria Raquel Marçal; de Freitas Mathias, Paulo Cezar.
Afiliação
  • Miranda RA; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • da Silva Franco CC; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Previate C; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Alves VS; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Francisco FA; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Moreira VM; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • de Moraes AMP; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
  • Gomes RM; Department of Physiological Sciences, Federal University of Goiás, Goiás, Brazil.
  • Picinato MC; Department of Physiology, Federal University of Pará, Altamira, Brazil.
  • Natali MRM; Department of Morphologic Sciences, State University of Maringá, Maringá, Brazil.
  • de Freitas Mathias PC; Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
Cell Physiol Biochem ; 49(1): 395-405, 2018.
Article em En | MEDLINE | ID: mdl-30153661
BACKGROUND/AIMS: Particulate matter (PM) is an important risk factor for immunological system imbalance due to its small size, which can reach more distal regions of the respiratory tract, independently of its chemical composition. Some studies have suggested that PM exposure is associated with an increased incidence of diabetes, especially in industrialized urban regions. However, studies regarding the effects of PM exposure during perinatal life on glucose metabolism are limited. We tested whether exposure to PM from an urban area with poor air quality during pregnancy and lactation could cause short- and long-term dysfunction in rat offspring. METHODS: Samples of < 10 µm PM were collected in an urban area of Cotonou, Benin (West Africa), and reconstituted in corn oil. Pregnant Wistar rats received 50 µg PM/day by gavage until the end of lactation. After birth, we analyzed the dams' biochemical parameters as well as those of their male offspring at 21 and 90 days of age. RESULTS: The results showed that PM exposure did not lead to several consequences in dams; however, the male offspring of both ages presented an increase of approximately 15% in body weight. Although the blood glucose levels remained unchanged, the insulin levels were increased 2.5- and 2-fold in PM exposure groups of both ages, respectively. HOMA-IR and HOMA-ß were also increased at both ages. We also demonstrated that the number, islet area and insulin immunodensity of pancreatic islets were significantly increased at both ages from PM exposure. CONCLUSION: Our data show that chronic PM exposure by the oral route during perinatal life in rats leads to glucose dyshomeostasis in male offspring both in early and later life. Thus, we suggest that an ambience with poor air quality, mainly where traffic is dense, can contribute to an increase in metabolic disease incidence.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Material Particulado / Glucose Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: Cell Physiol Biochem Assunto da revista: BIOQUIMICA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Material Particulado / Glucose Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: Cell Physiol Biochem Assunto da revista: BIOQUIMICA / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha