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The Nuclear Receptor Field: A Historical Overview and Future Challenges.
Mazaira, Gisela I; Zgajnar, Nadia R; Lotufo, Cecilia M; Daneri-Becerra, Cristina; Sivils, Jeffrey C; Soto, Olga B; Cox, Marc B; Galigniana, Mario D.
Afiliação
  • Mazaira GI; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (1428), Argentina.
  • Zgajnar NR; Instituto de Biología y Medicina Experimental- CONICET. Buenos Aires (1428), Argentina.
  • Lotufo CM; Instituto de Biología y Medicina Experimental- CONICET. Buenos Aires (1428), Argentina.
  • Daneri-Becerra C; Instituto de Biología y Medicina Experimental- CONICET. Buenos Aires (1428), Argentina.
  • Sivils JC; Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA.
  • Soto OB; Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA.
  • Cox MB; Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA.
  • Galigniana MD; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (1428), Argentina.
Nucl Receptor Res ; 52018.
Article em En | MEDLINE | ID: mdl-30148160
In this article we summarize the birth of the field of nuclear receptors, the discovery of untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of the three-domain structure of the receptors, and the properties of the Hsp90-based heterocomplex responsible for the overall structure of the oligomeric receptor and many aspects of the biological effects. The discovery and properties of the subfamily of receptors called orphan receptors is also outlined. Novel molecular aspects of the mechanism of action of nuclear receptors and challenges to resolve in the near future are discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nucl Receptor Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Egito
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nucl Receptor Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Egito