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Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy.
Steeb, Brenda; García-Cordero, Indira; Huizing, Marjolein C; Collazo, Lucas; Borovinsky, Geraldine; Ferrari, Jesica; Cuitiño, Macarena M; Ibáñez, Agustín; Sedeño, Lucas; García, Adolfo M.
Afiliação
  • Steeb B; Laboratory of Language Research (LILEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • García-Cordero I; Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • Huizing MC; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
  • Collazo L; Laboratory of Language Research (LILEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • Borovinsky G; Laboratory of Language Research (LILEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • Ferrari J; Laboratory of Language Research (LILEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • Cuitiño MM; Department of Language Speech, Institute of Cognitive Neurology, Buenos Aires, Argentina.
  • Ibáñez A; Laboratory of Language Research (LILEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
  • Sedeño L; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
  • García AM; Faculty of Psychology, Favaloro University, Buenos Aires, Argentina.
Front Psychol ; 9: 1345, 2018.
Article em En | MEDLINE | ID: mdl-30123155
Processing of nouns and action verbs can be differentially compromised following lesions to posterior and anterior/motor brain regions, respectively. However, little is known about how these deficits progress in the course of neurodegeneration. To address this issue, we assessed productive lexical skills in a patient with posterior cortical atrophy (PCA) at two different stages of his pathology. On both occasions, he underwent a structural brain imaging protocol and completed semantic fluency tasks requiring retrieval of animals (nouns) and actions (verbs). Imaging results were compared with those of controls via voxel-based morphometry (VBM), whereas fluency performance was compared to age-matched norms through Crawford's t-tests. In the first assessment, the patient exhibited atrophy of more posterior regions supporting multimodal semantics (medial temporal and lingual gyri), together with a selective deficit in noun fluency. Then, by the second assessment, the patient's atrophy had progressed mainly toward fronto-motor regions (rolandic operculum, inferior and superior frontal gyri) and subcortical motor hubs (cerebellum, thalamus), and his fluency impairments had extended to action verbs. These results offer unprecedented evidence of the specificity of the pathways related to noun and action-verb impairments in the course of neurodegeneration, highlighting the latter's critical dependence on damage to regions supporting motor functions, as opposed to multimodal semantic processes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Psychol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Psychol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça