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Cardiometabolic Risk Indicators for Kidney Disease in Mexican Patients with Type 2 Diabetes.
Velázquez-López, Lubia; Hernández-Sánchez, Rubí; Roy-García, Ivonne; Muñoz-Torres, Abril Violeta; Medina-Bravo, Patricia; Escobedo-de la Peña, Jorge.
Afiliação
  • Velázquez-López L; Unidad de Investigación en Epidemiología Clínica, Hospital Carlos Mac Gregor Sánchez Navarro, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address: lubia2002@yahoo.com.mx.
  • Hernández-Sánchez R; Hospital General de Zona y Medicina Familiar No 26, Instituto Mexicano del Seguro Social, Ciudad de México, México.
  • Roy-García I; División de desarrollo de la Investigación, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
  • Muñoz-Torres AV; Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
  • Medina-Bravo P; Departamento de Endocrinología, Hospital Infantil de México Federico Gómez, Secretaría de Salud (SSA), Ciudad de México, México.
  • Escobedo-de la Peña J; Unidad de Investigación en Epidemiología Clínica, Hospital Carlos Mac Gregor Sánchez Navarro, Instituto Mexicano del Seguro Social, Ciudad de México, México.
Arch Med Res ; 49(3): 191-197, 2018 04.
Article em En | MEDLINE | ID: mdl-30119978
INTRODUCTION: Kidney disease is one of the main complications in the diabetic patient. Risk factors such as obesity, dyslipidemia, and hyperglycemia have been associated with increased urinary albumin excretion (UAE) and decreased glomerular filtration rates (GFR). However, the data are inconsistent. The objective of this study was to identify the primary risk factors associated with kidney disease in Mexican patients with type 2 diabetes. METHODS: A cross-sectional study was done in 395 patients with type 2 diabetes from four primary-care clinics. From fasting venous blood samples, the serum creatinine, glucose, glycated hemoglobin (HbA1c), and lipid profiles were measured. The diagnosis of diabetic kidney disease (DKD) was made by measuring GFR with the CKD-EPI equation, and the UAE from the first morning urination, according to the KDIGO 2012 Guidelines. Weight and waist circumference (WC), as well as body composition through the method of bioimpedance, were measured. RESULTS: Fourteen percent of the study population was diagnosed with DKD. Higher age and higher triglyceride levels were associated with a greater risk of DKD (p <0.05). In a multivariate analysis, higher age (OR = 1.06, 95% CI 1.02-1.11), triglyceride level (OR = 2.4, 95% CI 1.18-4.92), WC (OR = 1.09, 95% CI 1.03-1.15), and smoking (OR 2.6, 95% CI 1.07-6.49) were associated to DKD. CONCLUSION: Higher triglyceride levels, greater WC, and smoking are risk factors associated to DKD. An early diagnosis and opportune treatment for several cardiometabolic risk factors associated to DKD and cardiovascular disease should be identified and treated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Arch Med Res Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos