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The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice.
Mendes-Junior, Leônidas Graças; Freitas-Lima, Leandro Ceotto; Oliveira, Janaína Ribeiro; Melo, Marcos B; Feltenberger, Jonh David; Brandi, Igor Viana; Carvalho, Bruna Mara Aparecida; Guimarães, André Luiz Sena; De Paula, Alfredo Maurício Batista; D'Angelis, Carlos Eduardo Mendes; Campagnole-Santos, Maria José; Souza Santos, Robson Augusto; Braga, Valdir Andrade; Santos, Sérgio Henrique Sousa.
Afiliação
  • Mendes-Junior LG; Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil.
  • Freitas-Lima LC; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
  • Oliveira JR; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
  • Melo MB; Physiology Department, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Feltenberger JD; Medical School, Touro University, Las Vegas, USA.
  • Brandi IV; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
  • Carvalho BMA; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil.
  • Guimarães ALS; Lab. Health Science, PPGCS, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil.
  • De Paula AMB; Lab. Health Science, PPGCS, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil.
  • D'Angelis CEM; Lab. Health Science, PPGCS, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil.
  • Campagnole-Santos MJ; Physiology Department, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Souza Santos RA; Physiology Department, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Braga VA; Department of Biotechnology, Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil.
  • Santos SHS; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil; Lab. Health Science, PPGCS, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Brazil. Electronic address: sergiosousas@hotmail.com.
Life Sci ; 209: 341-348, 2018 Sep 15.
Article em En | MEDLINE | ID: mdl-30118771
Diabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144.95 ±â€¯16.13 vs 92.90 ±â€¯18.95 mm Hg), low glucose tolerance (AUC = 1049.01 ±â€¯74.79 vs 710.50 ±â€¯52.57 a.u.), decreased insulin sensitivity (AUC = 429.83 ±â€¯35.22 vs 313.67 ±â€¯19.55 a.u.) and increased adiposity (epididymal fat weight 0.96 ±â€¯0.10 vs 0.59 ±â€¯0.06 OW/BW × 102), aspects present in metabolic syndrome. Cardiac evaluation showed diastolic dysfunction (E/A ratio = 1.20 vs 1.90 u.a.) and cardiomyocyte hypertrophy (cardiomyocyte area = 502.82 ±â€¯31.46 vs 385.58 ±â€¯22.11 µm2). Lastly, vascular reactivity was impaired with higher contractile response (136.10 ±â€¯3.49 vs 120.37 ±â€¯5.43%) and lower response to endothelium-dependent vasorelaxation (74.01 ±â€¯4.35 vs 104.84 ±â€¯3.57%). In addition, the diet was able to induce an inward coronary remodeling (vascular total area: SCNS 6185 ±â€¯800.6 vs HFHS 4085 ±â€¯213.7 µm2). Therefore, we conclude that HFHS short-term treatment was able to induce metabolic syndrome-like state, cardiomyopathy and vascular injury working as an important tool to study cardiometabolic diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloreto de Sódio na Dieta / Síndrome Metabólica / Dieta Hiperlipídica / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloreto de Sódio na Dieta / Síndrome Metabólica / Dieta Hiperlipídica / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda