Loss of S100A1 expression leads to Ca<sup>2+</sup> release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.

Hernández-Ochoa, Erick O; Melville, Zephan; Vanegas, Camilo; Varney, Kristen M; Wilder, Paul T; Melzer, Werner; Weber, David J; Schneider, Martin F

Loss of S100A1 expression leads to Ca²⁺ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.

Hernández-Ochoa, Erick O; Melville, Zephan; Vanegas, Camilo; Varney, Kristen M; Wilder, Paul T; Melzer, Werner; Weber, David J; Schneider, Martin F.

Afiliação

Hernández-Ochoa EO; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland.
Melville Z; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland.
Vanegas C; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland.
Varney KM; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland.
Wilder PT; Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Maryland.
Melzer W; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland.
Weber DJ; Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Maryland.
Schneider MF; Institute of Applied Physiology, Ulm University, Ulm, Germany.

Physiol Rep ; 6(15): e13822, 2018 08.

Article em En | MEDLINE | ID: mdl-30101473

Assuntos

Calmodulina/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Proteínas S100/fisiologia; Potenciais de Ação/fisiologia; Animais; Cálcio/metabolismo; Calorimetria/métodos; Acoplamento Excitação-Contração/fisiologia; Masculino; Camundongos Knockout; Camundongos Mutantes; Camundongos Transgênicos; Fibras Musculares Esqueléticas/metabolismo; Músculo Esquelético/metabolismo; Proteínas S100/deficiência

Palavras-chave

RyR1; Ca2+ release; S100A1; calmodulin; excitation-contraction coupling; isothermal calorimetry; skeletal muscle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calmodulina / Proteínas S100 / Canal de Liberação de Cálcio do Receptor de Rianodina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Physiol Rep Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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