Quantitative estimation by a standardized enzyme-linked immunosorbent assay of human T-cell lymphotropic virus type I antibodies in adult T-cell leukemia and acquired immune deficiency syndrome.
J Clin Microbiol
; 23(2): 212-6, 1986 Feb.
Article
em En
| MEDLINE
| ID: mdl-3009530
Sera from patients with adult T-cell leukemia and asymptomatic carriers of human T-cell lymphotropic virus type I (HTLV-I) from widely separated areas of the world reacted strongly in a standardized quantitative enzyme-linked immunosorbent assay procedure with HTLV-I viral antigen prepared from a strain isolated in the United States. There was a sharp differentiation of the values seen in the patients as compared with a normal population. Of the 35 acquired immune deficiency syndrome patients with Kaposi's sarcoma, only 2 were positive for HTLV-I antibodies in this test, and the distribution of the negative assay values in the other acquired immune deficiency syndrome patient sera was similar to that seen in the normal sera. Sera which contained extremely high levels of antibodies to other unrelated viruses (rubella virus, cytomegalovirus, and herpes simplex virus) all showed negative anti-HTLV-I results, in a pattern similar to the normal sera. Sera from patients with several autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis, thyroiditis) as well as those with infectious mononucleosis or myeloma all also showed the normal distribution of negative results, in spite of the presence of very high levels of the autoantibodies, etc., associated with their illnesses.
Palavras-chave
Acquired Immunodeficiency Syndrome; Americas; Antibodies--analysis; Biology; Developed Countries; Diseases; Examinations And Diagnoses; Florida; Hematological Effects; Hemic System; Hiv Infections; Immunity; Immunologic Factors; Laboratory Examinations And Diagnoses; North America; Northern America; Physiology; United States; Viral Diseases
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia
/
Síndrome da Imunodeficiência Adquirida
/
Deltaretrovirus
/
Anticorpos Antivirais
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
País/Região como assunto:
America do norte
/
Asia
/
Caribe ingles
/
Jamaica
/
Republica dominicana
Idioma:
En
Revista:
J Clin Microbiol
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
Estados Unidos