Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises.

Vale, A F; Ferreira, H H; Benetti, E J; Rebelo, A C S; Figueiredo, A C R; Barbosa, E C; Simões, K

Vale, A F; Ferreira, H H; Benetti, E J; Rebelo, A C S; Figueiredo, A C R; Barbosa, E C; Simões, K.

Afiliação

Vale AF; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Ferreira HH; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Benetti EJ; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Rebelo ACS; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Figueiredo ACR; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Barbosa EC; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.
Simões K; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás - UFG, Av. Esperança, s/n, Samambaia, CEP 74690-900, Goiânia, GO, Brasil.

Braz J Biol ; 79(2): 257-262, 2019.

Article em En | MEDLINE | ID: mdl-30088525

RESUMO

Increased oxygen consumption and activation of specific metabolic pathways during or after physical exercise lead to the formation of reactive oxygen and nitrogen species. An investigation was made into the effects of pequi oil supplementation in protecting liver cells against injury resulting from oxidative stress. The experiments involved 20 male adult Wistar rats ( Rattus norvegicus). The animals were divided into four experimental groups: Group 1: sedentary control group; Group 2: exercise control group; Group 3: supplemented sedentary group; and Group 4: supplemented exercise group. Supplementation consisted of pequi oil administered by oral gavage (400 mg). The animals of the exercised groups were subjected to 20 swimming sessions for 5 weeks (with progressive increase of 10 minutes until exhaustion). Samples were collected from the right hepatic lobe for histopathological analysis and determination of malondialdehyde levels. The histopathological analyses revealed that the animals of the exercised control group had moderate liver damage, while the animals of the supplemented exercised group had slight tissue damage, and the sedentary control and sedentary supplemented groups showed no tissue damage. The malondialdehyde levels showed higher and statistically significant in exercise control group when compared to the other evaluated groups (p<0.05). In conclusion the supplementation with pequi oil had a protective effect on liver cells against damage caused by oxygen free radicals during strenuous exercise, as demonstrated by the indicator of lipid peroxidation.

Assuntos

Antioxidantes/farmacologia; Ericales/química; Fígado/efeitos dos fármacos; Óleos de Plantas/farmacologia; Natação/fisiologia; Animais; Masculino; Ratos; Ratos Wistar

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Natação / Óleos de Plantas / Ericales / Fígado / Antioxidantes Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz J Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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