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Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks.
Khan, Shahzad A; Venancio, Emerson J; Fernandes, Eduardo V; Hirooka, Elisa Y; Oba, Alexandre; Flaiban, Karina K M C; Itano, Eiko N.
Afiliação
  • Khan SA; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. shahzadakbar@upr.edu.pk.
  • Venancio EJ; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. emersonj@uel.br.
  • Fernandes EV; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. eduardovignoto@uel.br.
  • Hirooka EY; Department of Food Science and Technology, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. elisahirooka@hotmail.com.
  • Oba A; Department of Zootechny, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. oba@uel.br.
  • Flaiban KKMC; Department of Preventive Veterinary Medicine, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. kkflaiban@uel.br.
  • Itano EN; Department of Pathologic Sciences, State University Londrina, P.O. Box 10.011, Londrina 86057-970, PR, Brazil. itano@uel.br.
Toxins (Basel) ; 10(8)2018 08 06.
Article em En | MEDLINE | ID: mdl-30082604
The mycotoxin, ochratoxin-A (OTA), produced by some fungi, and is a natural contaminant of many foods and animal feeds worldwide. Due to its toxic effects, the recommended maximum daily intake of OTA for poultry feeds is 0.1 mg OTA/kg (ECR2006/575/EC); this dose does not induce changes in hepatic/renal parameters, but decreases thymus size and serum globulin concentrations. Accordingly, in this study, we assessed quantitatively the total circulating IgY and IgA serum levels, in chicks consuming a 0.1 mg OTA/kg diet (limit) and higher doses (0.3⁻1.1 mg OTA/kg diet) for 14 or 21 days. We also evaluated other immunological parameters (thymus, bursa of Fabricius, and spleen weights and leukocyte profiles) at day 21. Decreased IgY serum levels were observed in all OTA-treated groups (p < 0.05). In the low-dose group, IgA levels were decreased on day 21, but not on day 14. The size of the thymus and the bursa of Fabricius was decreased in all OTA-treated groups (p < 0.05), whereas reduced spleen size and altered leukocyte profiles were detected only in the high-dose group (p < 0.05). We concluded that chronic exposure to OTA, even at the recommended highest dose, affected IgY and IgA production in chicks.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Imunoglobulinas / Ocratoxinas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina A / Imunoglobulinas / Ocratoxinas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça