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Preconceptional allergen immunization can induce offspring IL-17 secreting B cells (B17): do they share similarities with regulatory B10 cells?
Lira, Aline Aparecida de Lima; de-Oliveira, Marília Garcia; Inoue, Amanda Harumi Sabô; Beltrame, Giovanna Rossi; Duarte, Alberto José da Silva; Victor, Jefferson Russo.
Afiliação
  • Lira AAL; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • de-Oliveira MG; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Inoue AHS; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Beltrame GR; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Duarte AJDS; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil; Division of Pathology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • Victor JR; Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil; Division of Pathology, Medical School, University of Sao Paulo, Sao Paulo, Brazil; Division of Environmental Health, FMU, Laureate International Universities, Sao
Allergol Immunopathol (Madr) ; 46(5): 454-459, 2018.
Article em En | MEDLINE | ID: mdl-30082063
BACKGROUND: IL-17-producing B cells can be identified in both mice and human and were named B17 cells. The role of B17 cells still needs to be elucidated and its inflammatory or regulatory functions remain controversial. OBJECTIVE: We evaluate the effect of maternal immunization with OVA on offspring B cells that produces IL-17 and can show a regulatory potential by IL-10 production. METHODS: C57BL/6 WT, IL-10-/- or CD28-/- female mice were immunized or not with OVA in Alum, and immunized females were boosted after 10 and 20 days. Immunized and non-immunized females were mated, and pups from both groups were evaluated at 3 or 20 days old (d.o.). Some offspring from the aforementioned two groups were immunized with OVA at 3 d.o., boosted after 10 days and evaluated at 20 d.o. RESULTS: Maternal immunization with OVA induced offspring B cells to produce IL-17 at higher intensity compared to the control group of offspring at 3 d.o. This effect was maintained until 20 d.o. and even after neonatal immunization with OVA. The co-production of IL-10 on offspring IL-17+B cells is up-regulated in response to maternal immunization with OVA. Maternal immunization with OVA on IL-10-/- mice reveals reduced percentage and mean of fluorescence intensity of IL-17 on B cells of offspring. CONCLUSION: Preconception OVA immunization can induce offspring B cells that produce IL-17 at higher intensity and co-produce mainly IL-10. This could be the reason why B17 cells had been described in the literature with controversial roles upon their regulatory function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Interleucina-10 / Interleucina-17 / Hipersensibilidade / Imunidade Materno-Adquirida Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Singapura
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Interleucina-10 / Interleucina-17 / Hipersensibilidade / Imunidade Materno-Adquirida Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Singapura