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A plasmid-encoded mobile genetic element from Pseudomonas aeruginosa that confers heavy metal resistance and virulence.
Hernández-Ramírez, Karen C; Reyes-Gallegos, Rosa I; Chávez-Jacobo, Víctor M; Díaz-Magaña, Amada; Meza-Carmen, Víctor; Ramírez-Díaz, Martha I.
Afiliação
  • Hernández-Ramírez KC; Laboratorio de Microbiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
  • Reyes-Gallegos RI; Laboratorio de Microbiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
  • Chávez-Jacobo VM; Laboratorio de Microbiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
  • Díaz-Magaña A; Laboratorio de Microbiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
  • Meza-Carmen V; Laboratorio de Diferenciación Celular del Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
  • Ramírez-Díaz MI; Laboratorio de Microbiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico. Electronic address: marthaisela_ramirez@hotmail.com.
Plasmid ; 98: 15-21, 2018 06.
Article em En | MEDLINE | ID: mdl-30063910
Mobile plasmid-encoded elements are DNA segments that are transferred for horizontal gene transfer and that confer adaptive proprieties, as well as virulence and antibiotic and heavy metal resistance to bacteria. The conjugative plasmid pUM505, isolated from a clinical strain of Pseudomonas aeruginosa, possesses a putative 31.292 kb mobile element (denominated Mpe: Mobile plasmid- encoded element) that, in addition to possessing chr genes that confer chromate resistance to Pseudomonas, contains two putative mer operons that could confer mercury resistance. Moreover, the Mpe contains genes related previously with the virulence of both P. aeruginosa and Escherichia coli strains. In this work, we determined that Mpe from pUM505 was able to independently move to another DNA molecule, conferring chromate and mercury resistance to P. aeruginosa PAO1 and mercury resistance to E. coli JM101, suggesting that its transference might be beneficial to bacteria under certain environmental conditions. Additionally, the transference of Mpe increased the virulence of P. aeruginosa PAO1 against the nematode Caenorhabditis elegans, suggesting its contribution to the pathogenicity of P. aeruginosa. In this work, we describe a new mobile plasmid-encoded element that possesses the potential to be transferred by horizontal gene transference, which could provide bacteria with a wide variety of adaptive traits such as heavy metal resistance and virulence, which can be selective factors for the distribution and prevalence of this plasmid in diverse environments, including hospitals and heavy metal contaminated soils.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Pseudomonas aeruginosa / Infecções por Pseudomonas / Caenorhabditis elegans / Metais Pesados / Sequências Repetitivas Dispersas / Farmacorresistência Bacteriana Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Plasmid Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Pseudomonas aeruginosa / Infecções por Pseudomonas / Caenorhabditis elegans / Metais Pesados / Sequências Repetitivas Dispersas / Farmacorresistência Bacteriana Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Plasmid Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos