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Reaching Biocompatibility with Nanoclays: Eliminating the Cytotoxicity of Ir(III) Complexes.
Grüner, Malte C; Zanoni, Kassio P S; Borgognoni, Camila F; Melo, Cristiane C; Zucolotto, Valtencir; de Camargo, Andrea S S.
Afiliação
  • Grüner MC; Laboratory of Spectroscopy of Functional Materials (LEMAF), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
  • Zanoni KPS; Laboratory of Spectroscopy of Functional Materials (LEMAF), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
  • Borgognoni CF; Group of Nanomedicine and Nanotechnology (GNano), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
  • Melo CC; Group of Nanomedicine and Nanotechnology (GNano), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
  • Zucolotto V; Group of Nanomedicine and Nanotechnology (GNano), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
  • de Camargo ASS; Laboratory of Spectroscopy of Functional Materials (LEMAF), São Carlos Institute of Physics , University of São Paulo , Avenida Trabalhador Sãocarlense 400 , 13566-590 , São Carlos , Brazil.
ACS Appl Mater Interfaces ; 10(32): 26830-26834, 2018 Aug 15.
Article em En | MEDLINE | ID: mdl-30063820
Cyclometalated IrIII complexes are promising candidates for biomedical applications but high cytotoxicity limits their use as imaging and sensing agents. We herein introduce the use of Laponite as carrier for triplet-emitting cyclometalated IrIII complexes. Laponite is a versatile nanoplatform because of its biocompatibility, dispersion stability and large surface area that readily adsorbs functional nonpolar and cationic molecules. These inorganic-organic hybrid nanomaterials mask cytotoxicity, show efficient cell uptake and increase luminescent properties and photostability. By camouflaging intrinsic cytotoxicity, this simple method potentially extends the palette of available imaging and sensing dyes to any metal-organic complexes, especially those that are usually cytotoxic.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Irídio Tipo de estudo: Clinical_trials Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Irídio Tipo de estudo: Clinical_trials Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos