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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.
de Carvalho, Leonardo P; Tan, Sock Hwee; Ow, Ghim-Siong; Tang, Zhiqun; Ching, Jianhong; Kovalik, Jean-Paul; Poh, Sock Cheng; Chin, Chee-Tang; Richards, A Mark; Martinez, Eliana C; Troughton, Richard W; Fong, Alan Yean-Yip; Yan, Bryan P; Seneviratna, Aruni; Sorokin, Vitaly; Summers, Scott A; Kuznetsov, Vladimir A; Chan, Mark Y.
Afiliação
  • de Carvalho LP; Federal University of Sao Paulo State, Sao Paulo, Brazil.
  • Tan SH; National University Heart Center, Singapore, Singapore.
  • Ow GS; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Tang Z; Albert Einstein Hospital, São Paulo, Brazil.
  • Ching J; National University Heart Center, Singapore, Singapore.
  • Kovalik JP; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Poh SC; Bioinformatics Institute, ASTAR, Singapore.
  • Chin CT; Bioinformatics Institute, ASTAR, Singapore.
  • Richards AM; Institute of Molecular and Cell Biology, ASTAR, Singapore.
  • Martinez EC; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore.
  • Troughton RW; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore.
  • Fong AY; National University Heart Center, Singapore, Singapore.
  • Yan BP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore.
  • Seneviratna A; National Heart Centre Singapore, Singapore.
  • Sorokin V; National University Heart Center, Singapore, Singapore.
  • Summers SA; Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand.
  • Kuznetsov VA; Miller School of Medicine, University of Miami, Miami, Florida.
  • Chan MY; Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand.
JACC Basic Transl Sci ; 3(2): 163-175, 2018 Apr.
Article em En | MEDLINE | ID: mdl-30062203
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos