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Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome.
Bernini, Luciana J; Simão, Andréa N Colado; de Souza, Cínthia H B; Alfieri, Daniela F; Segura, Liliane G; Costa, Giselle N; Dichi, Isaias.
Afiliação
  • Bernini LJ; 1Programa de Mestrado em Ciência e Tecnologia de Leite e Derivados, Pitágoras-UNOPAR Londrina, Parana, 86041-140, Brazil.
  • Simão ANC; 2Departamento de Patologia,Análises Clínicas e Toxicologia,Universidade Estadual de Londrina,Londrina,Parana,86038-440, Brazil.
  • de Souza CHB; 1Programa de Mestrado em Ciência e Tecnologia de Leite e Derivados, Pitágoras-UNOPAR Londrina, Parana, 86041-140, Brazil.
  • Alfieri DF; 3Pesquisador do Laboratório de Imunologia Aplicada,Universidade Estadual de Londrina,Londrina,Parana,86038-440,Brazil.
  • Segura LG; 1Programa de Mestrado em Ciência e Tecnologia de Leite e Derivados, Pitágoras-UNOPAR Londrina, Parana, 86041-140, Brazil.
  • Costa GN; 1Programa de Mestrado em Ciência e Tecnologia de Leite e Derivados, Pitágoras-UNOPAR Londrina, Parana, 86041-140, Brazil.
  • Dichi I; 4Departamento de Medicina Interna,Universidade Estadual de Londrina,Londrina,Parana,86038-440, Brazil.
Br J Nutr ; 120(6): 645-652, 2018 09.
Article em En | MEDLINE | ID: mdl-30058513
Beneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects of Bifidobacterium lactis HN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 and P=0·03, respectively), hydroperoxides (P=0·02 and P=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx, P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion, B. lactis HN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Probióticos / Síndrome Metabólica / Bifidobacterium animalis / Inflamação Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Nutr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Probióticos / Síndrome Metabólica / Bifidobacterium animalis / Inflamação Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Nutr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido