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Cardiometabolic Risk Factors, Metabolic Syndrome, and Chronic Kidney Disease Progression in Children.
Lalan, Shwetal; Jiang, Shuai; Ng, Derek K; Kupferman, Fernanda; Warady, Bradley A; Furth, Susan; Mitsnefes, Mark M.
Afiliação
  • Lalan S; Division of Pediatric Nephrology, Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ; Department of Pediatrics, Brookdale University Hospital and Medical Center, Brooklyn, NY. Electronic address: slalan@phoenixchildrens.com.
  • Jiang S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  • Ng DK; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
  • Kupferman F; Department of Pediatrics, Brookdale University Hospital and Medical Center, Brooklyn, NY.
  • Warady BA; Division of Pediatric Nephrology, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO.
  • Furth S; Division of Pediatric Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
  • Mitsnefes MM; Division of Pediatric Nephrology and hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
J Pediatr ; 202: 163-170, 2018 11.
Article em En | MEDLINE | ID: mdl-30041938
OBJECTIVE: To estimate the prevalence of metabolic syndrome (MetS) and examine its association with chronic kidney disease progression in children enrolled in the Chronic Kidney Disease in Children study. STUDY DESIGN: MetS was defined as being overweight or obese and having ≥2 cardiometabolic risk factors (CMRFs). Incidence and prevalence of MetS were assessed using pairs of visits approximately 2 years apart. RESULTS: A total of 799 pairs of person-visits (contributed by 472 children) were included in the final analysis. Of these, 70% had a normal body mass index (BMI), 14% were overweight, and 16% were obese. At the first visit, the prevalence of MetS in the overweight group was 40% and in the obese group was 60%. In adjusted models, annual percent estimated glomerular filtration rate decline in those who had normal BMI and incident or persistent multiple CMRFs or those with persistent MetS was -6.33%, -6.46%, and -6.08% (respectively) compared with children who never had multiple CMRFs (-3.38%, P = .048, .045, and .036, respectively). Children with normal BMI and incident multiple CMRFs and those with persistent MetS had approximately twice the odds of fast estimated glomerular filtration rate decline (>10% per year) compared with those without multiple CMRFs and normal BMI. CONCLUSION: Children with chronic kidney disease have a high prevalence of MetS. These children as well as those with normal BMI but multiple CMRFs experience a faster decline in kidney function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Síndrome Metabólica / Insuficiência Renal Crônica / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Síndrome Metabólica / Insuficiência Renal Crônica / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos