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Association of Maternal Roux-en-Y Gastric Bypass with Obstetric Outcomes and Fluid Intelligence in Offspring.
Blume, Carina Andriatta; Machado, Brenda Moretto; da Rosa, Raíssa Ramos; Rigoni, Maisa Dos Santos; Casagrande, Daniela Schaan; Mottin, Cláudio Corá; Schaan, Beatriz D.
Afiliação
  • Blume CA; Post-Graduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, 2350, prédio 12, 4° andar, Porto Alegre, 90035-003, RS, Brazil. carinablume@hotmail.com.
  • Machado BM; Faculty of Nutrition, UFRGS, Porto Alegre, RS, Brazil.
  • da Rosa RR; Faculty of Psychology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Rigoni MDS; Faculty of Psychology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
  • Casagrande DS; Center for Obesity and Metabolic Syndrome, Hospital São Lucas, PUCRS, Porto Alegre, RS, Brazil.
  • Mottin CC; Center for Obesity and Metabolic Syndrome, Hospital São Lucas, PUCRS, Porto Alegre, RS, Brazil.
  • Schaan BD; School of Medicine, PUCRS, Porto Alegre, Brazil.
Obes Surg ; 28(11): 3611-3620, 2018 11.
Article em En | MEDLINE | ID: mdl-30030729
PURPOSE: The purpose of the study is to assess whether Roux-en-Y gastric bypass (RYGB) prior to pregnancy is associated with fluid intelligence in offspring. Additionally, perinatal and obstetric outcomes, and children nutritional status were evaluated. MATERIAL AND METHODS: Singleton births of women who underwent RYGB between 2000 and 2010 (BS) were matched to two control births by maternal age, delivery year, and gender. Control group 1 (CG1) and control group 2 (CG2) included women with a pre-pregnancy body mass index (BMI) < 35 kg/m2 and ≥ 35 kg/m2, respectively, who had never undergone bariatric surgery. RESULTS: Thirty-two children from each group (n = 96) were analyzed, mostly female (59%) and Caucasian (82%), with a mean age of 7 ± 2 years. Their general intelligence scores were similar after adjusting for sociodemographic confounders; family economic class was the strongest predictor (low: ß = - 20.57; p < 0.001; middle: ß = - 9.34; p = 0.019). Gestational diabetes mellitus (OR 0.06; 95% CI 0.03; 0.35) and hypertensive disorders (OR 0.09; 95% CI 0.01; 0.40) were less frequent in BS than CG2. Post-RYGB pregnancies were associated with lower birth weight (P = 0.021) than controls. Child overweight and obesity was higher (OR 4.59; 95% CI 1.55; 13.61; p = 0.006) in CG2 (78%) than CG1 (44%) and similar to BS (65%). CONCLUSIONS: RYGB prior to pregnancy was not associated with fluid intelligence in offspring. Prior RYGB was associated with a lower frequency of gestational diabetes mellitus and hypertensive disorders than in women with a pre-pregnancy BMI ≥ 35 kg/m2, as well as with lower birth weight than both control groups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Derivação Gástrica / Inteligência / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Child, preschool / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Derivação Gástrica / Inteligência / Obesidade Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Child, preschool / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos