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Zebrafish models: do we have valid paradigms for depression?
de Abreu, Murilo S; Friend, Ashton J; Demin, Konstantin A; Amstislavskaya, Tamara G; Bao, Wandong; Kalueff, Allan V.
Afiliação
  • de Abreu MS; Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Programs in Pharmacology and Environmental Sciences, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
  • Friend AJ; Tulane University School of Science and Engineering, New Orleans, LA, USA; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
  • Demin KA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Center, St. Petersburg, Russia.
  • Amstislavskaya TG; Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
  • Bao W; School of Pharmacy, Southwest University, Chongqing, China.
  • Kalueff AV; School of Pharmacy, Southwest University, Chongqing, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Center, St. Petersburg, Russia; Ural Federal University, Ekaterinburg, Ru
J Pharmacol Toxicol Methods ; 94(Pt 2): 16-22, 2018.
Article em En | MEDLINE | ID: mdl-30030185
Depression is a wide-spread, debilitating psychiatric disorder. Mainly rodent-based, experimental animal models of depression are extensively used to probe the pathogenesis of this disorder. Here, we emphasize the need for innovative approaches to studying depression, and call for a wider use of novel model organisms, such as the zebrafish (Danio rerio), in this field. Highly homologous to humans and rodents, zebrafish are rapidly becoming a valuable tool in translational neuroscience research, but have only recently been utilized in depression research. Multiple conceptual and methodological problems, however, arise in relation to separating putative zebrafish depression-like states from motor and social deficits or anxiety. Here, we examine recent findings and the existing challenges in this field, to encourage further research and the use of zebrafish as novel organisms in cross-species depression modeling.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Depressão / Modelos Animais de Doenças Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Depressão / Modelos Animais de Doenças Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos