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National Trends in Hospitalization for Fever and Neutropenia in Children with Cancer, 2007-2014.
Lekshminarayanan, Anusha; Bhatt, Parth; Linga, Vijay Gandhi; Chaudhari, Riddhi; Zhu, Brian; Dave, Mihir; Donda, Keyur; Savani, Sejal; Patel, Samir V; Billimoria, Zeenia C; Bhaskaran, Smita; Zaid-Kaylani, Samer; Dapaah-Siakwan, Fredrick; Bhatt, Neel S.
Afiliação
  • Lekshminarayanan A; Department of Internal Medicine, Functional Cholesterol, Diabetes, and Endocrinology Center, Springdale, OH.
  • Bhatt P; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.
  • Linga VG; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.
  • Chaudhari R; Department of Pediatrics, University of Connecticut, Hartford, CT.
  • Zhu B; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.
  • Dave M; Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY.
  • Donda K; Department of Pediatrics, University of Miami, Coral Gables, FL.
  • Savani S; Department of Public Health, New York University, New York, NY.
  • Patel SV; Department of Internal Medicine, Sparks Health Systems, Fort Smith, AR.
  • Billimoria ZC; Department of Pediatrics, University of Washington, Seattle, WA.
  • Bhaskaran S; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.
  • Zaid-Kaylani S; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.
  • Dapaah-Siakwan F; Department of Pediatrics, University of Miami, Coral Gables, FL.
  • Bhatt NS; Department of Pediatrics, Division of Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI. Electronic address: nbhatt@mcw.edu.
J Pediatr ; 202: 231-237.e3, 2018 11.
Article em En | MEDLINE | ID: mdl-30029861
OBJECTIVE: To assess the trends of inpatient resource use and mortality in pediatric hospitalizations for fever with neutropenia in the US from 2007 to 2014. STUDY DESIGN: Using National (Nationwide) Inpatient Sample (NIS) and International Classification of Diseases, Ninth Revision, Clinical Modification codes, we studied pediatric cancer hospitalizations with fever with neutropenia between 2007 and 2014. Using appropriate weights for each NIS discharge, we created national estimates of median cost, length of stay, and in-hospital mortality rates. RESULTS: Between 2007 and 2014, there were 104 315 hospitalizations for pediatric fever with neutropenia. The number of weighted fever with neutropenia hospitalizations increased from 12.9 (2007) to 18.1 (2014) per 100 000 US population. A significant increase in fever with neutropenia hospitalizations trend was seen in the 5- to 14-year age group, male sex, all races, and in Midwest and Western US hospital regions. Overall mortality rate remained low at 0.75%, and the 15- to 19-year age group was at significantly greater risk of mortality (OR 2.23, 95% CI 1.36-3.68, P = .002). Sepsis, pneumonia, meningitis, and mycosis were the comorbidities with greater risk of mortality during fever with neutropenia hospitalizations. Median length of stay (2007: 4 days, 2014: 5 days, P < .001) and cost of hospitalization (2007: $8771, 2014: $11 202, P < .001) also significantly increased during the study period. CONCLUSIONS: Our study provides information regarding inpatient use associated with fever with neutropenia in pediatric hospitalizations. Continued research is needed to develop standardized risk stratification and cost-effective treatment strategies for fever with neutropenia hospitalizations considering increasing costs reported in our study. Future studies also are needed to address the greater observed mortality in adolescents with cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Custos Hospitalares / Febre / Hospitalização / Neoplasias / Neutropenia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Custos Hospitalares / Febre / Hospitalização / Neoplasias / Neutropenia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos