Your browser doesn't support javascript.
loading
Immunoexpression of calcitonin and glucocorticoid receptors in central giant cell lesions of the jaws.
Batista Severo, Mara Luana; Lopes, Maria Luiza Diniz de Sousa; Miguel, Márcia Cristina da Costa; Germano, Adriano Rocha; Nogueira, Renato Luiz Maia; Turatti, Eveline; Cavalcante, Roberta Barroso; da Silveira, Éricka Janine Dantas.
Afiliação
  • Batista Severo ML; Postgraduate Program in Oral Pathology, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Lopes MLDS; Postgraduate Program in Oral Pathology, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Miguel MCDC; Postgraduate Program in Oral Pathology, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Germano AR; Oral and Maxillofacial Surgery Residence, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Nogueira RLM; Department of Dental Clinic, Discipline of Oral and Maxillofacial Surgery and Stomatology, Federal University of Ceara School of Dentistry, Fortaleza, CE, Brazil.
  • Turatti E; Department of Oral Pathology, School of Dentistry, University of Fortaleza, UNIFOR, Fortaleza, CE, Brazil.
  • Cavalcante RB; Department of Oral Pathology, School of Dentistry, University of Fortaleza, UNIFOR, Fortaleza, CE, Brazil.
  • da Silveira ÉJD; Postgraduate Program in Oral Pathology, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
J Oral Pathol Med ; 47(9): 907-913, 2018 Oct.
Article em En | MEDLINE | ID: mdl-30028524
BACKGROUND: This study analyzed the immunoexpression of calcitonin receptor (CTR) and glucocorticoid receptor (GR) in central giant cell lesions (CGCLs) and verified potential associations with patient's response to clinical treatment with intralesional injection of triamcinolone. MATERIALS AND METHODS: Fifty-four cases of CGCLs, including 22 non-aggressive, and 32 aggressive, were investigated by immunohistochemistry. RESULTS: Surgery was the therapeutic choice for 53.1% of the aggressive CGCLs, and 46.9% were submitted to the conservative treatment with intralesional triamcinolone injections. Among patients submitted to conservative treatment, 60% (n = 9) showed favorable response. CTR expression was observed in 68.51%, and GR in 94.44% of the total sample. There were no differences in the expression of CTR, neither GR in mononucleated stromal cells (MSCs) or multinucleated giant cells (MGCs), in relation to aggressiveness, treatment performed for and the response to conservative treatment. Both markers showed a positive correlation between their expression in MSCs and MGCs in the total sample (P < 0.0001). CTR expression on MSCs showed a positive correlation with MGCs in the aggressive and non-aggressive groups (P < 0.0001). CONCLUSIONS: Calcitonin receptor and GR expression were diffuse and similar in non-aggressive and aggressive cases, and it did not influence the response to clinical treatment with triamcinolone in the sample studied.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triancinolona / Imuno-Histoquímica / Granuloma de Células Gigantes / Doenças Maxilomandibulares / Receptores de Glucocorticoides / Células Gigantes / Receptores da Calcitonina Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triancinolona / Imuno-Histoquímica / Granuloma de Células Gigantes / Doenças Maxilomandibulares / Receptores de Glucocorticoides / Células Gigantes / Receptores da Calcitonina Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca