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Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.
Panizzutti, Bruna; Bortolasci, Chiara; Hasebe, Kyoko; Kidnapillai, Srisaiyini; Gray, Laura; Walder, Ken; Berk, Michael; Mohebbi, Mohammadreza; Dodd, Seetal; Gama, Clarissa; Magalhães, Pedro V; Cotton, Susan M; Kapczinski, Flávio; Bush, Ashley I; Malhi, Gin S; Dean, Olivia M.
Afiliação
  • Panizzutti B; 1Laboratory of Molecular Psychiatry,Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,Brazil.
  • Bortolasci C; 2Graduation Program in Health Sciences,State University of Londrina (UEL),Londrina,Brazil.
  • Hasebe K; 3Deakin University,School of Medicine,Centre for Molecular and Medical Research,Geelong,Australia.
  • Kidnapillai S; 3Deakin University,School of Medicine,Centre for Molecular and Medical Research,Geelong,Australia.
  • Gray L; 3Deakin University,School of Medicine,Centre for Molecular and Medical Research,Geelong,Australia.
  • Walder K; 3Deakin University,School of Medicine,Centre for Molecular and Medical Research,Geelong,Australia.
  • Berk M; 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon Health,Geelong,Australia.
  • Mohebbi M; 8Deakin University,Biostatistics Unit,Faculty of Health,Geelong,Australia.
  • Dodd S; 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon Health,Geelong,Australia.
  • Gama C; 1Laboratory of Molecular Psychiatry,Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,Brazil.
  • Magalhães PV; 1Laboratory of Molecular Psychiatry,Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,Brazil.
  • Cotton SM; 7Orygen Centre for Youth Mental Health,University of Melbourne,Parkville,Australia.
  • Kapczinski F; 1Laboratory of Molecular Psychiatry,Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,Brazil.
  • Bush AI; 5Department of Psychiatry,The University of Melbourne,Parkville,Australia.
  • Malhi GS; 10Academic Department of Psychiatry,Northern Sydney Local Health District,St Leonards,NSW,Australia.
  • Dean OM; 4Deakin University,School of Medicine,IMPACT Strategic Research Centre,Barwon Health,Geelong,Australia.
Acta Neuropsychiatr ; 30(6): 334-341, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30008280
OBJECTIVE: This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS: This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers. RESULTS: Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters. CONCLUSION: The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Transtorno Bipolar / Encefalite / Neurogênese Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropsychiatr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Transtorno Bipolar / Encefalite / Neurogênese Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropsychiatr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido