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Evaluating DNA evidence in a genetically complex population.
Hessab, T; Aranha, R S; Moura-Neto, R S; Balding, D J; Schrago, C G.
Afiliação
  • Hessab T; Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto de Pesquisa e Perícias em Genética Forense, DGPTC/PCERJ, Rio de Janeiro, RJ, Brazil. Electronic address: hessab@gmail.com.
  • Aranha RS; Escola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro, RJ, Brazil.
  • Moura-Neto RS; Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Balding DJ; Melbourne Integrative Genomics, School of BioSciences and School of Mathematics & Statistics, The University of Melbourne, Melbourne, Australia.
  • Schrago CG; Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Forensic Sci Int Genet ; 36: 141-147, 2018 09.
Article em En | MEDLINE | ID: mdl-29990826
In forensic genetics, the likelihood ratio (LR), measuring the value of DNA profile evidence, is computed from a database of allele frequencies. Here, we address the choice of database and adjustments for population structure and sample size in the context of Brazil. The Brazilian population underwent a complex process of colonization, migration and mating, which created an admixed genetic composition that makes it difficult to obtain an appropriate database for a given case. National databases are now available, as well as databases for many Brazilian states. However, those databases are not statistically random samples, and state boundaries may not accurately reflect the sub-structuring of genetic diversity. We compared the LR calculated using the relevant state-specific database with the statistics calculated when a national database and when international databases were used. We evaluated two methods of adjustment for population structure, due to Wright [13] and Balding and Nichols [14]. We also considered two adjustments for database sample size: the Balding size bias correction [15] and a minimum allele frequency [16]. Our results show that the use of a national database with the Balding and Nichols adjustment and θ = 0.002 generated lower LR values than did the state-specific database in more than 50% of the profiles simulated using the state-based allele frequencies, while θ = 0.01 produced lower LRs for more than 90% of the profiles. We conclude that the utilization of a national database for Brazilian cases can be justified in association with the appropriate adjustment for population structure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Impressões Digitais de DNA / Repetições de Microssatélites / Bases de Dados de Ácidos Nucleicos / Genética Populacional Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Forensic Sci Int Genet Assunto da revista: GENETICA / JURISPRUDENCIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Holanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Impressões Digitais de DNA / Repetições de Microssatélites / Bases de Dados de Ácidos Nucleicos / Genética Populacional Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Forensic Sci Int Genet Assunto da revista: GENETICA / JURISPRUDENCIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Holanda