Your browser doesn't support javascript.
loading
Polymorphisms in TWIST1 and ZEB1 Are Associated with Prognosis of Gastric Cancer Patients.
Romero, Sandra; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, V Gonzalo; Jara, Lilian; Berger, Zoltan; Gonzalez-Hormazabal, Patricio.
Afiliação
  • Romero S; Human Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago, Chile.
  • Musleh M; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile.
  • Bustamante M; Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Stambuk J; Department of Surgery, School of Medicine at Eastern Campus, University of Chile, Santiago, Chile.
  • Pisano R; Department of Surgery, San Juan de Dios Hospital, Santiago, Chile.
  • Lanzarini E; Department of Pathology, San Juan de Dios Hospital, Santiago, Chile.
  • Chiong H; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile.
  • Rojas J; Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Castro VG; Department of Surgery, Barros Luco Hospital, Santiago, Chile.
  • Jara L; Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Berger Z; Human Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago, Chile.
  • Gonzalez-Hormazabal P; Human Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, Santiago, Chile.
Anticancer Res ; 38(7): 3871-3877, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29970507
BACKGROUND/AIM: Epithelial-mesenchymal transition (EMT) program has been linked as a driver of metastatic dissemination by conferring migratory and invasive capacity to cancer cells. Gastric cancer (GC) patients with tumors expressing altered levels of EMT markers have low survival. This study aimed to assess if polymorphisms of CDH1, TWIST1, SNAIL2, ZEB1 and ZEB2 genes are associated with survival in GC patients. PATIENTS AND METHODS: A total of 153 individuals with diagnosis of GC were recruited in Santiago, Chile. All patients were genotyped using Infinium Global Screening Array (GSA). Twenty Tag SNPs of the studied genes were retrieved. RESULTS: Three SNPs were associated with survival: rs2526614 (TWIST1) (genotype CA + AA, adjusted HR=0.58, 95%CI=0.37-0.93), rs6953766 (TWIST1) (genotype GG, crude HR=2.02, 95%CI=1.06-3.82, adjusted HR=2.14, 95%CI=1.07-4.25), and rs431073 (ZEB1) (genotype AC + CC, crude HR=1.62, 95%CI=1.01-2.59, adjusted HR=1.96, 95%CI=1.18-3.25). CONCLUSION: To the best of our knowledge, this is the first study proposing a role of these SNPs in cancer prognosis. Their use as prognostic markers of GC survival warrants further investigation.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Proteínas Nucleares / Polimorfismo de Nucleotídeo Único / Proteína 1 Relacionada a Twist / Homeobox 1 de Ligação a E-box em Dedo de Zinco Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Grécia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Proteínas Nucleares / Polimorfismo de Nucleotídeo Único / Proteína 1 Relacionada a Twist / Homeobox 1 de Ligação a E-box em Dedo de Zinco Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Grécia