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Gold nanoparticles coupled with graphene quantum dots in organized medium to quantify aminoglycoside anti-biotics in yellow fever vaccine after solid phase extraction using a selective imprinted polymer.
Toloza, Carlos A T; Almeida, Joseany M S; Khan, Sarzamin; Dos Santos, Yasmin G; da Silva, Andrea R; Romani, Eric C; Larrude, Dunieskys G; Freire, Fernando L; Aucélio, Ricardo Q.
Afiliação
  • Toloza CAT; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil.
  • Almeida JMS; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil.
  • Khan S; Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Anbar, 23561, Pakistan.
  • Dos Santos YG; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil.
  • da Silva AR; Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET/RJ), 27600-000, Valença, RJ, Brazil.
  • Romani EC; SENAI Innovation Institute for Virtual Production Systems, Rio de Janeiro, 20961-020, Brazil.
  • Larrude DG; Graphene and Nanomaterials Research Center, Mackenzie University, 01302-907, São Paulo, Brazil.
  • Freire FL; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil.
  • Aucélio RQ; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil. Electronic address: .aucelior@puc-rio.br.
J Pharm Biomed Anal ; 158: 480-493, 2018 Sep 05.
Article em En | MEDLINE | ID: mdl-29960239
The determination of kanamycin sulfate was made indirectly by measuring its effect on photoluminescent amino functionalized graphene quantum dots (GQDs-amino) associated with gold nanoparticles (AuNPs) that were produced by the reduction of AuCl4 with NaBH4 in an aqueous dispersion of GQDs-amino (obtained by the pyrolysis of citric acid and glutathione) also containing the cationic surfactant CTAB. The AuNPs-GQDs-amino-CTAB system presents a suppressed photoluminescence that is amplified in the presence of kanamycin. Under optimized experimental conditions, the photoluminescence amplification of the nanomaterial system showed a linear response as a function of kanamycin concentration, covering three orders of magnitude (10-7 to 10-5 mol L-1). The use of solid phase extraction with a cartridge packed with aminoglycoside selective molecularly imprinted polymer ensured selectivity in determinations made on yellow-fever vaccine and veterinary pharmaceutical formulations. The analytical results were statistically similar to those obtained with an HPLC-based fluorescence method (after chemical derivatization). The proposed method is a simple, sensitive and selective approach that does not involve the use of toxic reagents employed for chemical derivatization of aminoglycoside antibiotics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conservantes Farmacêuticos / Canamicina / Técnicas Biossensoriais / Vacina contra Febre Amarela / Antibacterianos Tipo de estudo: Diagnostic_studies / Evaluation_studies Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conservantes Farmacêuticos / Canamicina / Técnicas Biossensoriais / Vacina contra Febre Amarela / Antibacterianos Tipo de estudo: Diagnostic_studies / Evaluation_studies Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido