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Effects of intratesticular injection of zinc-based solution in rats in combination with anti-inflammatory and analgesic drugs during chemical sterilization.
de Macêdo, Simone Regina Barros; de Lima, Luiz André Rodrigues; de Torres, Sandra Maria; de Oliveira, Vinícius Vasconcelos Gomes; de Morais, Rosana Nogueira; Peixoto, Christina Alves; Tenorio, Bruno Mendes; Junior, Valdemiro Amaro da Silva.
Afiliação
  • de Macêdo SRB; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
  • de Lima LAR; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
  • de Torres SM; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
  • de Oliveira VVG; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
  • de Morais RN; Department of Physiology, Federal University of Paraná, Curitiba, Paraná, Brazil.
  • Peixoto CA; Laboratory of Ultrastructure, Aggeu Magalhães Research Center (CPqAM), Recife, Pernambuco, Brazil.
  • Tenorio BM; Department of Morphology, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
  • Junior VADS; Department of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, Brazil.
Vet World ; 11(5): 649-656, 2018 May.
Article em En | MEDLINE | ID: mdl-29915504
AIM: Chemical sterilization is a non-surgical method of contraception based on compounds injected into the testis to induce infertility. However, these injections can cause discomfort and pain able to impair the recovery of animals after this treatment. The objective of this study was to investigate if anti-inflammatories or pain relievers inhibited the sterilizing effect of zinc gluconate-based solution on the testis. MATERIALS AND METHODS: Adult rats were treated in groups: G1 (control), G2 (dimethyl sulfoxide + dipyrone); G3 (dipyrone/zinc); G4 (dipyrone + celecoxib/zinc); G5 (dipyrone + meloxicam/zinc), and G6 (dipyrone + dexamethasone/zinc) in a single dose per day during 7 days. Animals were analyzed at 7, 15, and 30 days after treatments. RESULTS: The zinc-induced a widespread testicular degeneration and decreased testosterone levels even in combination with anti-inflammatories or pain relievers. Testis, epididymis, prostate, and seminal vesicle had a weight reduction. The anti-inflammatory effect of dexamethasone interfered in the desired action of zinc gluconate in the 1st 15 days and celecoxib up to 7 days. CONCLUSION: Meloxicam plus dipyrone did not impair the chemical sterilization based on zinc gluconate, and it can be used to reduce nociceptive effects in animals after chemical sterilization.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet World Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet World Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Índia