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Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study.
Serrano, Norma C; Guio-Mahecha, Elizabeth; Quintero-Lesmes, Doris Cristina; Becerra-Bayona, Silvia; Paez, María C; Beltran, Mónica; Herrera, Víctor M; Leon, Lydia J; Williams, David; Casas, Juan P.
Afiliação
  • Serrano NC; Fundación Cardiovascular de Colombia, Floridablanca, Colombia; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Colombia. Electronic address: normaserrano@fcv.org.
  • Guio-Mahecha E; Fundación Cardiovascular de Colombia, Floridablanca, Colombia.
  • Quintero-Lesmes DC; Fundación Cardiovascular de Colombia, Floridablanca, Colombia.
  • Becerra-Bayona S; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Colombia.
  • Paez MC; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Colombia.
  • Beltran M; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Colombia.
  • Herrera VM; Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Colombia.
  • Leon LJ; Farr Institute of Health Informatics, University College London, London, UK.
  • Williams D; Institute for Women's Health, University College London Hospital, London, UK.
  • Casas JP; Farr Institute of Health Informatics, University College London, London, UK.
Atherosclerosis ; 276: 189-194, 2018 09.
Article em En | MEDLINE | ID: mdl-29914672
BACKGROUND AND AIMS: Pre-eclampsia constitutes a leading cause of maternal and perinatal morbidity and mortality. Pre-eclampsia susceptibility is believed to be associated with altered lipid profiles and abnormal lipid metabolism via lipid peroxidation that leads to endothelial dysfunction. The goal of this study was to evaluate the association of maternal blood lipid and apolipoprotein levels with pre-eclampsia in a large-scale study. METHODS: Using data from a large case-control study (1366 cases of pre-eclampsia and 1741 normotensive controls), the association between the distributions of eight lipid fractions and pre-eclampsia risk was evaluated using adjusted logistic regression models. Pre-eclampsia was defined as blood pressure ≥140/90 mmHg and proteinuria ≥300 mg/24 h (>1 + dipstick). Sub-group analyses were conducted for early (<34 weeks) and late (≥37 weeks) pre-eclampsia, estimating the effect of 1 standard deviation increase in log-transformed lipid fraction levels in adjusted multinomial regression models. RESULTS: After adjustment for potential confounders, concentrations of triglycerides, apolipoprotein E (ApoE) and the relationship between apolipoprotein B and A1 (ApoB/ApoA1) showed the strongest associations with pre-eclampsia, particularly for those cases with an early onset. CONCLUSIONS: Higher levels of triglycerides, ApoE and the ApoB/ApoA1 ratio are associated with an increased risk of pre-eclampsia. Further studies that allow for a causal inference are needed to confirm or refute the aetiological role of blood lipids in pre-eclampsia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas / Pré-Eclâmpsia / Triglicerídeos Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Pregnancy País/Região como assunto: America do sul / Colombia Idioma: En Revista: Atherosclerosis Ano de publicação: 2018 Tipo de documento: Article País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas / Pré-Eclâmpsia / Triglicerídeos Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Pregnancy País/Região como assunto: America do sul / Colombia Idioma: En Revista: Atherosclerosis Ano de publicação: 2018 Tipo de documento: Article País de publicação: Irlanda