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Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Nascimento, Bruna P P; Bocco, Barbara M L C; Fernandes, Gustavo W; Fonseca, Tatiana L; McAninch, Elizabeth A; Cardoso, Carolina V; Bondan, Eduardo F; Nassif, Renata J; Cysneiros, Roberta M; Bianco, Antonio C; Ribeiro, Miriam O.
Afiliação
  • Nascimento BPP; Graduate Program of Translational Medicine, Department of Medicine, Federal University of São Paulo, São Paulo-SP, Brazil.
  • Bocco BMLC; Developmental Disorders Program, Center of Biological Sciences and Health, Mackenzie Presbyterian University, São Paulo-SP, Brazil.
  • Fernandes GW; Division of Endocrinology and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
  • Fonseca TL; Division of Endocrinology and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
  • McAninch EA; Division of Endocrinology and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
  • Cardoso CV; Division of Endocrinology and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
  • Bondan EF; Department of Environmental and Experimental Pathology, Paulista University, São Paulo-SP, Brazil.
  • Nassif RJ; Department of Environmental and Experimental Pathology, Paulista University, São Paulo-SP, Brazil.
  • Cysneiros RM; Neuroscience Sector, Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo-SP, Brazil.
  • Bianco AC; Developmental Disorders Program, Center of Biological Sciences and Health, Mackenzie Presbyterian University, São Paulo-SP, Brazil.
  • Ribeiro MO; Division of Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois.
Endocrinology ; 159(8): 3090-3104, 2018 08 01.
Article em En | MEDLINE | ID: mdl-29905787
Status epilepticus (SE) is an abnormally prolonged seizure that results from either a failure of mechanisms that terminate seizures or from initiating mechanisms that inherently lead to prolonged seizures. Here we report that mice experiencing a 3 hours of SE caused by pilocarpine exhibit a rapid increase in expression of type 2 iodothyronine deiodinase gene (Dio2) and a decrease in the expression of type 3 iodothyronine deiodinase gene in hippocampus, amygdala and prefrontal cortex. Type 3 iodothyronine deiodinase in hippocampal sections was seen concentrated in the neuronal nuclei, typical of ischemic injury of the brain. An unbiased analysis of the hippocampal transcriptome of mice undergoing 3 hours of SE revealed a number of genes, including those involved with response to oxidative stress, cellular homeostasis, cell signaling, and mitochondrial structure. In contrast, in mice with targeted disruption of Dio2 in astrocytes (Astro D2KO mouse), the highly induced genes in the hippocampus were related to inflammation, apoptosis, and cell death. We propose that Dio2 induction caused by SE accelerates production of T3 in different areas of the central nervous system and modifies the hippocampal gene expression profile, affecting the balance between adaptive and maladaptive mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Tri-Iodotironina / Expressão Gênica / Hipocampo / Iodeto Peroxidase Limite: Animals Idioma: En Revista: Endocrinology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Tri-Iodotironina / Expressão Gênica / Hipocampo / Iodeto Peroxidase Limite: Animals Idioma: En Revista: Endocrinology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos