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Low bone mineral density and associated factors in patients with haemophilia in Colombia.
Sossa Melo, C L; Wandurraga, E A; Peña, A M; Jiménez, S I; Salazar, L A; Ochoa, M E; Luna-Gonzalez, M L; Ortiz, M L; Morales, K; Ayala-Castillo, M; Reyes, D L; Chalela, C M.
Afiliação
  • Sossa Melo CL; Division of Hematology and Hematopoietic Stem Cell Transplantation, Department of Internal Medicine, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Wandurraga EA; Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Carlos Ardila Lulle, Bucaramanga, Colombia.
  • Peña AM; Department of Endocrinology, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Jiménez SI; Division of Hematology and Hematopoietic Stem Cell Transplantation, Department of Internal Medicine, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Salazar LA; Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Carlos Ardila Lulle, Bucaramanga, Colombia.
  • Ochoa ME; Division of Hematology and Hematopoietic Stem Cell Transplantation, Department of Internal Medicine, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Luna-Gonzalez ML; Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Carlos Ardila Lulle, Bucaramanga, Colombia.
  • Ortiz ML; Division of Hematology and Hematopoietic Stem Cell Transplantation, Department of Internal Medicine, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Morales K; Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Carlos Ardila Lulle, Bucaramanga, Colombia.
  • Ayala-Castillo M; Department of Public Health, School of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Reyes DL; Research Department, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia.
  • Chalela CM; Hematology and Hematopoietic Stem Cell Transplantation Unit, Clinica Carlos Ardila Lulle, Bucaramanga, Colombia.
Haemophilia ; 24(4): e222-e229, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29902356
INTRODUCTION: Patients with haemophilia may have lower levels of bone mineral density (BMD) compared with the general population. Moreover, haemophilic patients have increased risk factors for low bone mineral density (LBMD) such as arthropathy and resulting immobility, increasing their risk for osteoporosis and fractures. AIM: To assess the prevalence of LBMD and associated risk factors among a group of Colombian haemophilic patients. METHODS: In this case-control study, 90 patients with haemophilia A and B, over the age of five, were recruited. Controls were healthy participants matched by age, gender, body mass index (BMI), socioeconomic status, and race. All participants underwent dual energy X-ray absorptiometry (DXA) and the Global Physical Activity Questionnaire. Blood tests were collected to evaluate LBMD determinants in cases. RESULTS: BMD was lower in cases than in the control group. BMD of femoral necks was 0.907 g/cm2 in cases vs. 1.020 g/cm2 in controls (P = .019), and BMD of hips 0.930 g/cm2 in cases vs. 1030 g/cm2 in controls (P = .019). The greater the severity of haemophilia, the lower BMD in spine, femoral neck, and hips. Elevated C-protein levels were found in 44.1% of patients with LBMD and 14.8% with normal BMD (P = .003). The study found an adjusted prevalence ratio of 2.11, indicating that haemophilic patients are two times more likely to have LBMD (CI95% = 1.43-3.11 P < .001). CONCLUSION: Results from the present study showed that haemophilia was associated with a higher frequency of LBMD. Severity of haemophilia, haemophilic arthropathy, and elevated C-reactive protein levels was directly associated with LBMD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Hemofilia B / Hemofilia A Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Colombia Idioma: En Revista: Haemophilia Assunto da revista: HEMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Hemofilia B / Hemofilia A Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Colombia Idioma: En Revista: Haemophilia Assunto da revista: HEMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido