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Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats.
Cardoso-Teixeira, Ana Carolina; Ferreira-da-Silva, Francisco Walber; Peixoto-Neves, Dieniffer; Oliveira-Abreu, Klausen; Pereira-Gonçalves, Átila; Coelho-de-Souza, Andrelina Noronha; Leal-Cardoso, José Henrique.
Afiliação
  • Cardoso-Teixeira AC; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza-CE 60741-903, Brazil. carol.cardoso@uece.br.
  • Ferreira-da-Silva FW; Civil Engineering Department, State University of Vale do Acaraú, Sobral-CE 62042-280, Brazil. walber_ferreira@uvanet.br.
  • Peixoto-Neves D; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. dneves@uthsc.edu.
  • Oliveira-Abreu K; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza-CE 60741-903, Brazil. klausen.abreu@aluno.uece.br.
  • Pereira-Gonçalves Á; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza-CE 60741-903, Brazil. atila.pereira@aluno.uece.br.
  • Coelho-de-Souza AN; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza-CE 60741-903, Brazil. andrelinanoronha@gmail.com.
  • Leal-Cardoso JH; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza-CE 60741-903, Brazil. jose.cardoso@uece.br.
Molecules ; 23(6)2018 Jun 13.
Article em En | MEDLINE | ID: mdl-29899230
The present study used isometric tension recording to investigate the vasorelaxant effect of limonene (LM), carveol (CV), and perillyl alcohol (POH) on contractility parameters of the rat aorta, focusing in particular on the structure-activity relationship. LM, CV, and POH showed a reversible inhibitory effect on the contraction induced by electromechanical and pharmacomechanical coupling. In the case of LM, but not CV and POH, this effect was influenced by preservation of the endothelium. POH and CV but not LM exhibited greater pharmacological potency on BayK-8644-induced contraction and on electromechanical coupling than on pharmacomechanical coupling. In endothelium-denuded preparations, the order of pharmacological potency on electrochemical coupling was LM < CV < POH. These compounds inhibited also, with grossly similar pharmacological potency, the contraction induced by phorbol ester dibutyrate. The present results suggest that LM, CV and POH induced relaxant effect on vascular smooth muscle by means of different mechanisms likely to include inhibition of PKC and IP3 pathway. For CV and POH, hydroxylated compounds, it was in electromechanical coupling that the greater pharmacological potency was observed, thus suggesting a relative specificity for a mechanism likely to be important in electromechanical coupling, for example, blockade of voltage-dependent calcium channel.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Torácica / Vasodilatadores / Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil) / Contração Isométrica / Músculo Liso Vascular Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Torácica / Vasodilatadores / Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil) / Contração Isométrica / Músculo Liso Vascular Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça