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Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry.
Rossato, Luana; Moreno, Leandro Ferreira; Jamalian, Azadeh; Stielow, Benjamin; de Almeida, Sandro Rogério; de Hoog, Sybren; Freeke, Joanna.
Afiliação
  • Rossato L; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands luana.farma@hotmail.com.
  • Moreno LF; Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Jamalian A; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
  • Stielow B; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
  • de Almeida SR; Thermo Fisher Scientific, Landsmeer, The Netherlands.
  • de Hoog S; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
  • Freeke J; Thermo Fisher Scientific, Landsmeer, The Netherlands.
mSphere ; 3(3)2018 06 27.
Article em En | MEDLINE | ID: mdl-29898987
Sporothrix brasiliensis is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. S. brasiliensis has shown a high degree of virulence in a mouse model compared to the remaining Sporothrix species, including the ancestral species, Sporothrix schenckii The present paper investigates a genomic and expressed-proteome comparison of S. brasiliensis to S. schenckii Using bottom-up proteomics, we found 60 proteins exclusively expressed in S. brasiliensis No significant genomic differences were found among the genes coding for this protein set. A comparison with literature data identified nine proteins that are known to be involved in virulence and immune evasion in other species, several of which had not yet been reported for the Sporothrix species analyzed.IMPORTANCE Sporotrichosis is an important disease in Brazil that is caused by fungi of the genus Sporothrix and affects cats and humans. Our work investigated the proteins differentially expressed by S. brasiliensis in order to find out why this species is more virulent and pathogenic than S. schenckii We verified a set of proteins that may be related to immune escape and that can explain the high virulence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sporothrix / Proteínas Fúngicas / Fatores de Virulência / Evasão da Resposta Imune Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: MSphere Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sporothrix / Proteínas Fúngicas / Fatores de Virulência / Evasão da Resposta Imune Tipo de estudo: Prognostic_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: MSphere Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos